NPAS4 Antibody [N408/79 (Formerly sold as S408-79)]
NPAS4 Antibody [N408/79 (Formerly sold as S408-79)] is a mouse monoclonal antibody directed against NPAS4, offered by Assay Genie for research applications. Reported applications include WB, IHC and ICC/IF. Reported reactivity: Human, Mouse and Rat. Supplied as IgG1, purified by Protein G.
NPAS4 (Neuronal PAS Domain Protein 4) is a brain-specific transcription factor that plays a pivotal role in regulating activity-dependent gene expression critical for synaptic plasticity, learning, and memory. As a member of the bHLH-PAS family, NPAS4 is rapidly induced by neuronal activity and orchestrates the formation and maintenance of inhibitory synapses, particularly in excitatory neurons. NPAS4 modulates the excitatory-inhibitory balance in neural circuits by promoting the expression of genes involved in GABAergic synapse development. It also activates the CNS midline enhancer and regulates drebrin, a cytoskeletal protein essential for dendritic spine morphology. Dysregulation of NPAS4 has been linked to neurodevelopmental and neuropsychiatric disorders, including schizophrenia, autism spectrum disorder, and cognitive impairment. In neurodegenerative disease research, NPAS4 is gaining attention for its neuroprotective roles in response to excitotoxic stress and its potential to modulate synaptic resilience. Its activity-dependent expression profile makes it a promising biomarker and therapeutic target for preserving synaptic integrity in aging and disease. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µg. For research use only; not for diagnostic or therapeutic procedures.
Product Name:
NPAS4 Antibody [N408/79 (Formerly sold as S408-79)]
Product SKU:
STMA00172
Size:
100 µg
Target:
NPAS4
Host Species:
Mouse
Antibody Type:
Monoclonal
Clone ID:
N408/79 (Formerly sold as S408-79)
Research Areas:
Cell Signaling, Epigenetics and Nuclear Signaling, Neuroscience
Buffer:
PBS pH7.4, 50% glycerol, 0.1% sodium azide
Storage & Shipping:
Store at -20°C. Shipped on Blue Ice or 4°C. Conjugated variants should be stored according to the product label.
Format:
Liquid
Applications:
WB, IHC, ICC/IF
Antibody Isotype:
IgG1
Purification:
Protein G Purified
Concentration:
1 mg/ml
Reactivity:
Human, Mouse, Rat
Recommended Dilution:
WB (1:1000), ICC/IF(1:100); optimal dilutions for assays should be determined by the user.
Specificity:
Detects ~90kDa.
Guarantee:
12 months from date of dispatch
Immunogen:
Fusion protein amino acids 597-802 (C-terminus) of rat Npas4.
Immunogen Species:
Rat
Accession Number:
NP_705890.1
Gene ID:
2630-04-16 00:00:00
Swiss-Prot:
Q8CJH6
Cellular Localization:
Cytoplasm | Nucleus
Tissue Specificity:
Highly expressed in the brain, with lower expression found in endocrine tissue.
Alternative Names:
Neuronal PAS domain-containing protein 4, Neuronal PAS4, Class E basic helix-loop-helix protein 79, HLH-PAS transcription factor NXF, PAS domain-containing protein 10, Limbic-enhanced PAS protein, bHLHe79, PASD10, LE-PAS
