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BNP Rabbit Polyclonal Antibody (CAB2179)

SKU:
CAB2179
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Signal Transduction
  • Signal Transduction Antibodies 2 Anti-BNP Antibody CAB2179
  • Signal Transduction Antibodies 2 Anti-BNP Antibody CAB2179
  • Signal Transduction Antibodies 2 Anti-BNP Antibody CAB2179
  • Signal Transduction Antibodies 2 Anti-BNP Antibody CAB2179
  • Signal Transduction Antibodies 2 Anti-BNP Antibody CAB2179
€139 - €419
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:BNP Rabbit Polyclonal Antibody
SKU:CAB2179
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 35-134 of human BNP (NP_002512.1).
Sequence:ASDL ETSG LQEQ RNHL QGKL SELQ VEQT SLEP LQES PRPT GVWK SREV ATEG IRGH RKMV LYTL RAPR SPKM VQGS GCFG RKMD RISS SSGL GCKV LRRH
Tested Applications:WB IHC-P IF/ICC ELISA
Recommended Dilution:WB,1:1000 - 1:5000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200
Synonyms:BNP; Iso-ANP
Positive Sample:Mouse brain
Conjugate:Unconjugated
Cellular Localization:Secreted.
Calculated MW:15kDa
Observed MW:14kDa

This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The presence of myocardial injury is a significant predictor of mortality in hospitalized coronavirus disease 2019 (COVID-19) patients, and there is evidence of increased levels of natriuretic peptide B in hospitalized non-survivor COVID-19 patients. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis.

Purification Method:Affinity purification
Gene ID:4879
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Product ImageWestern blot analysis of lysates from Mouse brain, using BNP Rabbit pAb (CAB2179) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.

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