The NRG1 Antibody (PAC023116) is a valuable tool for researchers studying the role of NRG1, a cell surface protein involved in cell proliferation, differentiation, and survival. This polyclonal antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in various applications, including Western blot analysis.NRG1, also known as neuregulin 1, is a critical factor in the development and function of the nervous system. It plays a key role in neurodevelopmental processes, including neuronal migration and synapse formation. Dysregulation of NRG1 signaling has been implicated in various neurological disorders, making it a target of interest in neuroscience research.
By binding to the NRG1 protein, the PAC023116 Antibody enables the detection and analysis of NRG1 expression in different cell types, providing valuable insights into its function and potential therapeutic applications. Researchers studying neurobiology, neurodevelopmental disorders, and neurodegenerative diseases can benefit from using this antibody to further their understanding of NRG1-mediated pathways and mechanisms.
Synthesized peptide derived from human NRG1 isoform-10.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from SKOV3 cells, using NRG1 isoform-10 antibody.
Immunohistochemical analysis of paraffin-embedded human brain tissue using NRG1 isoform-10 antibody.
Background:
The protein encoded by this gene is a membrane glycoprotein that that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD).
The protein encoded by this gene is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD). [provided by RefSeq, Apr 2016]
Acetylcholine receptor-inducing activity; ARIA; Breast cancer cell differentiation factor p45; Glial growth factor; Heregulin; HRG; Neu differentiation factor; Sensory and motor neuron-derived factor
