| Background: | This gene encodes an enzyme that belongs to the Nudix hydrolase superfamily. Members of this superfamily catalyze the hydrolysis of nucleoside diphosphates, including substrates like 8-oxo-dGTP, which are a result of oxidative damage, and can induce base mispairing during DNA replication, causing transversions. The encoded enzyme is a negative regulator of thiopurine activation and toxicity. Mutations in this gene result in poor metabolism of thiopurines, and are associated with thiopurine-induced early leukopenia. Multiple pseudogenes of this gene have been identified. |
| UniProt Protein Function: | NUDT15: Mediates the hydrolysis of some nucleoside diphosphate derivatives. Can degrade 8-oxo-dGTP in vitro, suggesting that it may remove an oxidatively damaged form of guanine (7,8-dihydro-8- oxoguanine) from DNA and the nucleotide pool, thereby preventing misincorporation of 8-oxo-dGTP into DNA thus preventing A:T to C:G transversions. Its substrate specificity in vivo however remains unclear. May have a role in DNA synthesis and cell cycle progression through the interaction with PCNA. Belongs to the Nudix hydrolase family.Protein type: Hydrolase; EC 3.6.1.55Chromosomal Location of Human Ortholog: 13q14.2Cellular Component: cytosolMolecular Function: 8-oxo-7,8-dihydroguanine triphosphatase activity; nucleoside-diphosphatase activityBiological Process: dGTP catabolic process |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes an enzyme that belongs to the Nudix hydrolase superfamily. Members of this superfamily catalyze the hydrolysis of nucleoside diphosphates, including substrates like 8-oxo-dGTP, which are a result of oxidative damage, and can induce base mispairing during DNA replication, causing transversions. The encoded enzyme is a negative regulator of thiopurine activation and toxicity. Mutations in this gene result in poor metabolism of thiopurines, and are associated with thiopurine-induced early leukopenia. Multiple pseudogenes of this gene have been identified. [provided by RefSeq, Apr 2016] |
| UniProt Code: | Q9NV35 |
| NCBI GenInfo Identifier: | 68565944 |
| NCBI Gene ID: | 55270 |
| NCBI Accession: | Q9NV35.1 |
| UniProt Secondary Accession: | Q9NV35,Q32Q27, Q6P2C9, A2RUR6 |
| UniProt Related Accession: | Q9NV35 |
| Molecular Weight: | 18,609 Da |
| NCBI Full Name: | Probable 8-oxo-dGTP diphosphatase NUDT15 |
| NCBI Synonym Full Names: | nudix hydrolase 15 |
| NCBI Official Symbol: | NUDT15Â Â |
| NCBI Official Synonym Symbols: | MTH2; NUDT15DÂ Â |
| NCBI Protein Information: | probable 8-oxo-dGTP diphosphatase NUDT15 |
| UniProt Protein Name: | Probable 8-oxo-dGTP diphosphatase NUDT15 |
| UniProt Synonym Protein Names: | 7,8-dihydro-8-oxoguanine-triphosphatase NUDT15; MutT homolog 2; MTH2; Nucleoside diphosphate-linked moiety X motif 15; Nudix motif 15 |
| Protein Family: | Nudix hydrolase |
| UniProt Gene Name: | NUDT15Â Â |
| UniProt Entry Name: | NUD15_HUMAN |
