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Anti-NUDT21 Antibody (CAB4482)

SKU:
CAB4482
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
NUDT21
CFIM25
CPSF5
Research Area:
Developmental Biology
  • Developmental Biology Anti-NUDT21 Antibody CAB4482
  • Developmental Biology Anti-NUDT21 Antibody CAB4482
  • Developmental Biology Anti-NUDT21 Antibody CAB4482
€139 - €419
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Description

Product Name:NUDT21 Rabbit pAb
Product Code:CAB4482
Size:20uL, 50uL, 100uL
Synonyms:NUDT21, CFIM25, CPSF5
Applications:WB, IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-227 of human NUDT21 (NP_008937.1).
Applications:WB, IHC
Recommended Dilutions:WB 1:200 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HepG2, A-549, Mouse testis, Rat testis
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-227 of human NUDT21 (NP_008937.1).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MSVV PPNR SQTG WPRG VTQF GNKY IQQT KPLT LERT INLY PLTN YTFG TKEP LYEK DSSV AARF QRMR EEFD KIGM RRTV EGVL IVHE HRLP HVLL LQLG TTFF KLPG GELN PGED EVEG LKRL MTEI LGRQ DGVL QDWV IDDC IGNW WRPN FEPP QYPY IPAH ITKP KEHK KLFL VQLQ EKAL FAVP KNYK LVAA PLFE LYDN APGY GPII SSLP QLLS RFNF IYN
Gene ID:11051
Uniprot:O43809
Cellular Location:Nucleus
Calculated MW:26kDa
Observed MW:26KDa
UniProt Protein Function:CFIM25: Component of the cleavage factor Im (CFIm) complex that plays a key role in pre-mRNA 3'-processing. Involved in association with CPSF6 or CPSF7 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. NUDT21/CPSF5 binds to cleavage and polyadenylation RNA substrates. The homodimer mediates simultaneous sequence-specific recognition of two 5'-UGUA-3' elements within the pre-mRNA. Binds to, but does not hydrolyze mono- and di-adenosine nucleotides. May have a role in mRNA export. Belongs to the Nudix hydrolase family. CPSF5 subfamily.
UniProt Protein Details:

Protein type:Spliceosome; RNA-binding; RNA splicing

Chromosomal Location of Human Ortholog: 16q12.2

Cellular Component: nucleoplasm; centrosome; nucleus; paraspeckles; mRNA cleavage factor complex

Molecular Function:mRNA binding; protein binding; protein homodimerization activity; hydrolase activity; RNA binding; histone deacetylase binding; AU-rich element binding

Biological Process: nuclear mRNA splicing, via spliceosome; transcription from RNA polymerase II promoter; RNA splicing; gene expression; mRNA polyadenylation; mRNA 3'-end processing; mRNA processing; termination of RNA polymerase II transcription; protein tetramerization

NCBI Summary:The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. This gene encodes the 25kD subunit of the protein complex, which is composed of four polypeptides. [provided by RefSeq, Jul 2008]
UniProt Code:O43809
NCBI GenInfo Identifier:74735411
NCBI Gene ID:11051
NCBI Accession:O43809.1
UniProt Secondary Accession:O43809,Q6IB85, Q6NE84,
UniProt Related Accession:O43809
Molecular Weight:227
NCBI Full Name:Cleavage and polyadenylation specificity factor subunit 5
NCBI Synonym Full Names:nudix (nucleoside diphosphate linked moiety X)-type motif 21
NCBI Official Symbol:NUDT21  
NCBI Official Synonym Symbols:CPSF5; CFIM25  
NCBI Protein Information:cleavage and polyadenylation specificity factor subunit 5; nudix motif 21; CPSF 25 kDa subunit; pre-mRNA cleavage factor Im (25kD); cleavage factor Im complex 25 kDa subunit; pre-mRNA cleavage factor Im, 25kD subunit; pre-mRNA cleavage factor Im 25 kDa subunit; nucleoside diphosphate-linked moiety X motif 21; cleavage and polyadenylation specific factor 5, 25 kDa; cleavage and polyadenylation specific factor 5, 25 kD subunit; cleavage and polyadenylation specificity factor 25 kDa subunit
UniProt Protein Name:Cleavage and polyadenylation specificity factor subunit 5
UniProt Synonym Protein Names:Cleavage and polyadenylation specificity factor 25 kDa subunit; CFIm25; CPSF 25 kDa subunit; Nucleoside diphosphate-linked moiety X motif 21; Nudix motif 21; Pre-mRNA cleavage factor Im 25 kDa subunit
Protein Family:Nudix hydrolase
UniProt Gene Name:NUDT21  
UniProt Entry Name:CPSF5_HUMAN

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