Opugotamig (Research-Grade) is a research-grade biosimilar monoclonal antibody targeting Folate receptor alpha. Reactivity: Human. Supplied as a liquid in 0.01M PBS pH 7.4. Applications: ELISA, flow cytometry, functional assays and in vivo research. Endotoxin: < 10 EU/mg. Purity: >95% purity as determined by SDS-PAGE. For research use only.
Folate receptor alpha (FOLR1) is a ~29 kDa protein. Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation. FOLR1 is the therapeutic target of mirvetuximab soravtansine (Elahere).
Product Name:
Opugotamig (Research-Grade)
SKU:
GXBS02332
Size:
100 µg, 1 mg
Antibody Type:
Monoclonal Antibody
Target:
Folate receptor alpha
Isotype:
Immunoglobulin (G1_L-kappa)_scFvkh-G1(h-CH2-CH3)
Host Species:
Chimeric
Reactivity:
Human
Applications:
ELISA, FACS, Functional assay, Research in vivo
Expression Host:
Mammalian cells
Synonyms:
Biparatopic, Bivalent, 2779564-38-2
Purity:
>95% purity as determined by SDS-PAGE.
Endotoxin Level:
< 10 EU/mg
Formulation:
0.01M PBS pH 7.4
State of Matter:
Liquid
Regulatory Status:
For research use only. Not suitable for clinical or therapeutic use.
Product Preparation:
Protein A/G purified from cell culture supernatant.
Storage and Handling:
Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fusion-[human activin receptor type 2-A (activin receptor type IIA, ACTR-IIA) extracellular domain (ECD) fragment (1-109) engineered varian]2-IgG1-Fc (Fragment constant)
