UniProt Protein Function: | OSCAR: Regulator of osteoclastogenesis which plays an important bone-specific function in osteoclast differentiation. Belongs to the leukocyte receptor complex/polymeric immunogobulin receptor (PIR/LRC) family. 7 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integral; Receptor, misc.Chromosomal Location of Human Ortholog: 19q13.42Cellular Component: plasma membrane; integral to membrane |
UniProt Protein Details: | |
NCBI Summary: | Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex protein family that plays critical roles in the regulation of both innate and adaptive immune responses. The encoded protein may play a role in oxidative stress-mediated atherogenesis as well as monocyte adhesion. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013] |
UniProt Code: | Q8IYS5 |
NCBI GenInfo Identifier: | 311033418 |
NCBI Gene ID: | 126014 |
NCBI Accession: | Q8IYS5.3 |
UniProt Secondary Accession: | Q8IYS5,Q5GRG5, Q8N763, Q8NHL4, Q8WXQ0, Q8WXQ1, Q8WXQ2 B7WNS2 |
UniProt Related Accession: | Q8IYS5 |
Molecular Weight: | 30,481 Da |
NCBI Full Name: | Osteoclast-associated immunoglobulin-like receptor |
NCBI Synonym Full Names: | osteoclast associated, immunoglobulin-like receptor |
NCBI Official Symbol: | OSCARÂ Â |
NCBI Official Synonym Symbols: | PIGR3; PIgR-3Â Â |
NCBI Protein Information: | osteoclast-associated immunoglobulin-like receptor; poly-Ig receptor 3; polymeric immunoglobulin receptor 3; osteoclast associated receptor OSCAR-S1; osteoclast associated receptor OSCAR-S2 |
UniProt Protein Name: | Osteoclast-associated immunoglobulin-like receptor |
UniProt Synonym Protein Names: | Polymeric immunoglobulin receptor 3 |
Protein Family: | Protein |
UniProt Gene Name: | OSCARÂ Â |
UniProt Entry Name: | OSCAR_HUMAN |