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Anti-OXA1L Antibody (CAB6300)

SKU:
CAB6300
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
  • Cell Biology Antibodies 10 Anti-OXA1L Antibody CAB6300
  • Cell Biology Antibodies 10 Anti-OXA1L Antibody CAB6300
  • Cell Biology Antibodies 10 Anti-OXA1L Antibody CAB6300
€139 - €419
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Description

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Antibody Name:Anti-OXA1L Antibody
Antibody SKU:CAB6300
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 396-495 of human OXA1L (NP_005006.3).
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:10 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:BT-474, MCF7, HepG2, A-549, 293T, Mouse kidney, Mouse liver, Mouse heart
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 396-495 of human OXA1L (NP_005006.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:PAVR TVLK IPQR VVHD LDKL PPRE GFLE SFKK GWKN AEMT RQLR EREQ RMRN QLEL AARG PLRQ TFTH NPLL QPGK DNPP NIPS SSSK PKSK YPWH DTLG
Gene ID:5018
Uniprot:Q15070
Cellular Location:Mitochondrion inner membrane, Multi-pass membrane protein
Calculated MW:28kDa/46kDa/48kDa
Observed MW:42kDa
Synonyms:OXA1L, OXA1
Background:This gene encodes an evolutionarily conserved protein that is localized to the inner mitochondrial membrane. The encoded protein is essential for the translocation of the N-terminal tail of subunit 2 of cytochrome c oxidase, and is involved in the assembly of the cytochrome c oxidase and ATPase complexes of the mitochondrial respiratory chain.
UniProt Protein Function:OXA1L: Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome oxidase. Required for the correct biogenesis of ATP synthase and complex I in mitochondria. Belongs to the OXA1/ALB3/YidC family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Mitochondrial; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 14q11.2

Cellular Component: protein complex; mitochondrion; mitochondrial membrane; mitochondrial respiratory chain

Molecular Function:protein binding; protein homodimerization activity

Biological Process: mitochondrial proton-transporting ATP synthase complex assembly; mitochondrial respiratory chain complex I assembly; negative regulation of oxidoreductase activity; aerobic respiration; protein complex assembly; protein insertion into membrane; negative regulation of ATPase activity; protein tetramerization

UniProt Code:Q15070
NCBI GenInfo Identifier:38372882
NCBI Gene ID:5018
NCBI Accession:Q15070.3
UniProt Secondary Accession:Q15070,B4DPA2,
UniProt Related Accession:Q15070
Molecular Weight:435
NCBI Full Name:Mitochondrial inner membrane protein OXA1L
NCBI Synonym Full Names:oxidase (cytochrome c) assembly 1-like
NCBI Official Symbol:OXA1L  
NCBI Official Synonym Symbols:OXA1  
NCBI Protein Information:mitochondrial inner membrane protein OXA1L; hsa; OXA1Hs; OXA1-like protein; oxidase assembly 1-like protein
UniProt Protein Name:Mitochondrial inner membrane protein OXA1L
UniProt Synonym Protein Names:Hsa; OXA1Hs; Oxidase assembly 1-like protein; OXA1-like protein
Protein Family:Mitochondrial inner membrane protein
UniProt Gene Name:OXA1L  
UniProt Entry Name:OXA1L_HUMAN
Anti-OXA1L Antibody (CAB6300)Western blot analysis of extracts of various cell lines, using OXA1L antibody (CAB6300) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 60s.
Anti-OXA1L Antibody (CAB6300)Immunohistochemistry of paraffin-embedded rat liver using OXA1L antibody (CAB6300) at dilution of 1:100 (40x lens).
Anti-OXA1L Antibody (CAB6300)Immunofluorescence analysis of NIH/3T3 cells using OXA1L antibody (CAB6300) at dilution of 1:100. Blue: DAPI for nuclear staining.

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