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PAK1 Rabbit Polyclonal Antibody (CAB0809)

SKU:
CAB0809
Product Type:
Antibody
Reactivity:
Human
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Death
  • Cell Death Antibodies 1 Anti-PAK1 Antibody CAB0809
  • Cell Death Antibodies 1 Anti-PAK1 Antibody CAB0809
€139 - €419
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:PAK1 Rabbit Polyclonal Antibody
SKU:CAB0809
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 130-250 of human PAK1 (NP_001122092.1).
Sequence:FYNS KKTS NSQK YMSF TDKS AEDY NSSN ALNV KAVS ETPA VPPV SEDE DDDD DDAT PPPV IAPR PEHT KSVY TRSV IEPL PVTP TRDV ATSP ISPT ENNT TPPD ALTR NTEK QKKK PKMS D
Tested Applications:WB ELISA
Recommended Dilution:WB,1:500 - 1:1000
Synonyms:IDDMSSD; p65-PAK; PAKalpha; alpha-PAK; PAK1
Positive Sample:K-562,C6
Conjugate:Unconjugated
Cellular Localization:Cell junction, Cell membrane, Cell projection, Cytoplasm, focal adhesion, invadopodium, ruffle membrane.
Calculated MW:61kDa
Observed MW:68kDa

This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Mutations in this gene have been associated with macrocephaly, seizures, and speech delay. Overexpression of this gene is also reported in many cancer types, and particularly in breast cancer. Alternative splicing results in multiple transcript variants.

Purification Method:Affinity purification
Gene ID:5058
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of extracts of various cell lines, using PAK1 antibody (CAB0809) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.

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