PBR Rabbit Monoclonal Antibody (CAB4881)

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CAB4881
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Description

Technical Manual

PBR Rabbit Monoclonal Antibody

Product Name:PBR Rabbit Monoclonal Antibody
Product SKU:CAB4881
Size:20uL, 50 uL
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Background:

Present mainly in the mitochondrial compartment of peripheral tissues, the protein encoded by this gene interacts with some benzodiazepines and has different affinities than its endogenous counterpart. The protein is a key factor in the flow of cholesterol into mitochondria to permit the initiation of steroid hormone synthesis. Alternatively spliced transcript variants have been reported; one of the variants lacks an internal exon and is considered non-coding, and the other variants encode the same protein. [provided by RefSeq, Feb 2012]

Immunogen:A synthesized peptide derived from human PBR
Sequence:

Email for sequence

Gene ID:706
Swiss Prot:P30536
Synonyms:BPBS; BZRP; DBI; IBP; MBR; PBR; PBS; PKBS; PTBR; mDRC; pk18
Calculated MW:18kDa
Observed MW:18KDa
Reactivity:Human, Mouse
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Application Key:Western blotting Immunohistochemistry Immunofluorescence 
Positive Samples:HeLa, 293T, Mouse lung, Mouse liver, Mouse spleen
Cellular Location:

Product Images

PBR Rabbit Monoclonal Antibody (CAB4881)

Western blot - PBR Rabbit mAb (CAB4881)

Uniprot Information

UniProt Protein Function:TSPO: Responsible for the manifestation of peripheral-type benzodiazepine recognition sites and is most likely to comprise binding domains for benzodiazepines and isoquinoline carboxamides. May play a role in the transport of porphyrins and heme. Plays a role in the transport of cholesterol across mitochondrial membranes in steroidogenic cells. Belongs to the TspO/BZRP family. Interacts with BZRAP1. May interact with STAR. Interacts with MOST-1. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Mitochondrial; Receptor, misc.; Membrane protein, integral; Apoptosis; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 22q13.31

Cellular Component: cytoplasm; integral to membrane; intracellular membrane-bound organelle; mitochondrial outer membrane; mitochondrion; nuclear membrane

Molecular Function:androgen binding; benzodiazepine receptor activity; cholesterol binding; protein binding

Biological Process: adrenal gland development; aging; anion transport; apoptosis; axon regeneration in the peripheral nervous system; behavioral response to pain; cell proliferation; chloride transport; glial cell migration; heme biosynthetic process; lipid transport; negative regulation of nitric oxide biosynthetic process; negative regulation of protein ubiquitination; negative regulation of tumor necrosis factor production; positive regulation of apoptosis; positive regulation of calcium ion transport; positive regulation of mitochondrial depolarization; protein targeting to mitochondrion; regulation of cholesterol transport; regulation of steroid biosynthetic process; response to drug; response to manganese ion; response to progesterone stimulus; response to testosterone stimulus; response to vitamin B1; steroid biosynthetic process; steroid metabolic process

NCBI Summary:Present mainly in the mitochondrial compartment of peripheral tissues, the protein encoded by this gene interacts with some benzodiazepines and has different affinities than its endogenous counterpart. The protein is a key factor in the flow of cholesterol into mitochondria to permit the initiation of steroid hormone synthesis. Alternatively spliced transcript variants have been reported; one of the variants lacks an internal exon and is considered non-coding, and the other variants encode the same protein. [provided by RefSeq, Feb 2012]
UniProt Code:P30536
NCBI GenInfo Identifier:313104268
NCBI Gene ID:706
NCBI Accession:P30536.3
UniProt Secondary Accession:P30536,Q53Y59, Q6ICF9, Q96TF6,
UniProt Related Accession:P30536
Molecular Weight:10,537 Da
NCBI Full Name:Translocator protein
NCBI Synonym Full Names:translocator protein
NCBI Official Symbol:TSPO 
NCBI Official Synonym Symbols:DBI; IBP; MBR; PBR; PBS; BPBS; BZRP; PKBS; PTBR; mDRC; pk18 
NCBI Protein Information:translocator protein
UniProt Protein Name:Translocator protein
UniProt Synonym Protein Names:Mitochondrial benzodiazepine receptor; PKBS; Peripheral-type benzodiazepine receptor; PBR
UniProt Gene Name:TSPO 
UniProt Entry Name:TSPOA_HUMAN
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Additional Information

Product type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
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