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Anti-PDXP Antibody (CAB17455)

SKU:
CAB17455
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
  • Cell Biology Antibodies 7 Anti-PDXP Antibody CAB17455
  • Cell Biology Antibodies 7 Anti-PDXP Antibody CAB17455
  • Cell Biology Antibodies 7 Anti-PDXP Antibody CAB17455
  • Cell Biology Antibodies 7 Anti-PDXP Antibody CAB17455
  • Cell Biology Antibodies 7 Anti-PDXP Antibody CAB17455
€139 - €419
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Description

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Antibody Name:Anti-PDXP Antibody
Antibody SKU:CAB17455
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human PDXP (NP_064711.1).
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse brain, Rat brain
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human PDXP (NP_064711.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:VETA SGRQ ALVV GKPS PYMF ECIT ENFS IDPA RTLM VGDR LETD ILFG HRCG MTTV LTLT GVSR LEEA QAYL AAGQ HDLV PHYY VESI ADLT EGLE D
Gene ID:57026
Uniprot:Q96GD0
Cellular Location:
Calculated MW:32kDa
Observed MW:32KDa
Synonyms:CIN, PLP, dJ37E16.5, PDXP
Background:Pyridoxal 5-prime-phosphate (PLP) is the active form of vitamin B6 that acts as a coenzyme in maintaining biochemical homeostasis. The preferred degradation route from PLP to 4-pyridoxic acid involves the dephosphorylation of PLP by PDXP.
UniProt Protein Function:PDXP: Protein serine phosphatase that dephosphorylates 'Ser-3' in cofilin and probably also dephosphorylates phospho-serine residues in DSTN. Regulates cofilin-dependent actin cytoskeleton reorganization. Required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phospho-threonines in LIMK1. Does not dephosphorylate peptides containing phospho- tyrosine. Pyridoxal phosphate phosphatase. Has some activity towards pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PMP) and pyridoxine 5'-phosphate (PNP), with a highest activity with PLP followed by PNP. Homodimer. Ubiquitous. Highly expressed in all the regions of central nerve system except the spinal cord. Also expressed at high level in liver and testis. In fetus, it is weakly expressed in all organs except brain. Inhibited by NaF, Zn(2+), Ca(2+), Mn(2+) and EDTA. Belongs to the HAD-like hydrolase superfamily.
UniProt Protein Details:

Protein type:Cell cycle regulation; Cofactor and Vitamin Metabolism - vitamin B6; EC 3.1.3.3; EC 3.1.3.74; Protein phosphatase, Ser/Thr (non-receptor)

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: actin cytoskeleton; cleavage furrow; cytosol; lamellipodium; midbody; plasma membrane

Molecular Function:heat shock protein binding; magnesium ion binding; phosphoprotein phosphatase activity; protein binding; pyridoxal phosphatase activity

Biological Process: actin rod formation; positive regulation of actin filament depolymerization; protein amino acid dephosphorylation; pyridoxal phosphate catabolic process; regulation of cytokinesis; regulation of mitosis

NCBI Summary:Pyridoxal 5-prime-phosphate (PLP) is the active form of vitamin B6 that acts as a coenzyme in maintaining biochemical homeostasis. The preferred degradation route from PLP to 4-pyridoxic acid involves the dephosphorylation of PLP by PDXP (Jang et al., 2003 [PubMed 14522954]).[supplied by OMIM, Mar 2008]
UniProt Code:Q96GD0
NCBI GenInfo Identifier:10092677
NCBI Gene ID:57026
NCBI Accession:NP_064711.1
UniProt Secondary Accession:Q96GD0,Q9UGY2,
UniProt Related Accession:Q96GD0
Molecular Weight:33.7 kDa
NCBI Full Name:pyridoxal phosphate phosphatase
NCBI Synonym Full Names:pyridoxal phosphatase
NCBI Official Symbol:PDXP  
NCBI Official Synonym Symbols:CIN; PLP; dJ37E16.5  
NCBI Protein Information:pyridoxal phosphate phosphatase
UniProt Protein Name:Pyridoxal phosphate phosphatase
UniProt Synonym Protein Names:Chronophin
Protein Family:Pyridoxal phosphate phosphatase
UniProt Gene Name:PDXP  
Anti-PDXP Antibody (CAB17455)Western blot analysis of extracts of various cell lines, using PDXP Polyclonal Antibody (CAB17455) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
Anti-PDXP Antibody (CAB17455)Immunohistochemistry of paraffin-embedded Mouse kidney using PDXP Rabbit pAb (CAB17455) at dilution of 1:100 (40x lens).
Anti-PDXP Antibody (CAB17455)Immunohistochemistry of paraffin-embedded Rat lung using PDXP Rabbit pAb (CAB17455) at dilution of 1:100 (40x lens).
Anti-PDXP Antibody (CAB17455)Immunohistochemistry of paraffin-embedded Human colon using PDXP Rabbit pAb (CAB17455) at dilution of 1:100 (40x lens).
Anti-PDXP Antibody (CAB17455)Immunofluorescence analysis of L929 cells using PDXP Rabbit pAb (CAB17455) at dilution of 1:100. Blue: DAPI for nuclear staining.

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