The Anti-Mouse CD106 Antibody (M/K-2.7) offered by Assay Genie is a vital tool for researchers studying CD106, also known as vascular cell adhesion molecule-1 (VCAM-1). This monoclonal antibody, developed for mouse samples, is specifically designed for use in flow cytometry and immunohistochemistry applications. It targets the CD106 protein, facilitating the precise detection and analysis of VCAM-1 expression in various tissues and cell types.CD106, a cell surface adhesion molecule, plays a crucial role in the immune response by mediating the adhesion of leukocytes to the endothelium. Its involvement in inflammatory processes and immune cell recruitment makes it a key player in diseases such as atherosclerosis, autoimmune disorders, and cancer.
Understanding the expression and function of CD106 is essential for unraveling its role in these pathological conditions and exploring its potential as a therapeutic target.The Anti-Mouse CD106 Antibody (M/K-2.7) from Assay Genie provides researchers with a reliable tool to investigate the intricate mechanisms involving CD106 in immune cell adhesion and inflammation. With its high specificity and sensitivity, this antibody enables precise and accurate analysis of VCAM-1 expression, making it an indispensable resource for studies in immunology, vascular biology, and disease research.
Product Title:
PE Anti-Mouse CD106 Antibody [M/K-2.7]
SKU:
AGEL3140
Size:
50 Tests, 100 Tests, 200 Tests
Clone No:
M/K-2.7
Synonyms:
Vascular cell adhesion protein 1;Vcam1;V-CAM 1;VCAM-1;CD106;
Host Species:
Rat
Reactivity:
Mouse
Application:
FCM
Isotype:
Rat IgG1, κ
Isotype Control:
PE Rat IgG1, κ Isotype Control[HRPN]
Form:
Liquid
Conjugation:
PE
Recommended Use:
Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:
Swissprot:
P29533
Gene ID:
22329
Storage Buffer:
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:
Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:
CD106 is a 110 kD glycosylphosphatidylinositol (GPI)-linked transmembrane protein, also known as VCAM-1 and INCAM-110. It is constitutively expressed on bone marrow stromal cells, myeloid progenitors, splenic dendritic cells, activated endothelial cells, as well as some lymphocytes. CD106 expression can be upregulated on endothelial cells by inflammatory cytokines. CD106 is involved in adhesion and acts as a counter-receptor for VLA-4 (α4/β1 integrin) and LPAM-1 (α4/β7 integrin).
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