Description

PerCP/Cyanine5.5 Anti-Human CD274/PD-L1 Antibody [29E.2A3]

The PERCP-Cyanine5.5 Anti-Human CD274 (PD-L1) Antibody (29E.2A3) offered by AssayGenie is a cutting-edge tool for researchers studying the PD-L1 protein, a critical immune checkpoint receptor involved in immune response regulation. This antibody, developed specifically for human samples, is a valuable addition to studies in immunology, oncology, and related fields.PD-L1, also known as programmed death-ligand 1, plays a pivotal role in modulating immune responses by interacting with its receptor PD-1 on T cells, leading to immune evasion and tolerance in various diseases, including cancer. The 29E.2A3 antibody, carefully crafted for high reactivity and specificity, enables precise detection and analysis of PD-L1 expression in different cell types and tissues, providing researchers with invaluable insights into immune regulation mechanisms.

With its potential applications in immunotherapy, biomarker discovery, and personalized medicine, the PERCP-Cyanine5.5 Anti-Human CD274 (PD-L1) Antibody (29E.2A3) offers a powerful resource for advancing our understanding of immune checkpoint pathways and exploring novel therapeutic strategies for combating diseases characterized by dysregulated immune responses.

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Product Title:	PerCP/Cyanine5.5 Anti-Human CD274/PD-L1 Antibody [29E.2A3]
SKU:	AGEL2263
Size:	20 Tests, 100 Tests, 200 Tests
Clone No:	29E.2A3
Synonyms:	B7-H1; PD-L1;Programmed cell death ligand 1;B7 homolog 1;B7-H; B7H1; PDL1; PDCD1L1; PDCD1LG1;
Host Species:	Mouse
Reactivity:	Human
Application:	FCM

Isotype:	Mouse IgG2b, κ
Isotype Control:	PerCP/Cyanine5.5 Mouse IgG2b, κ Isotype Control[MPC-11]
Form:	Liquid
Conjugation:	PerCP/Cyanine 5.5
Recommended Use:	Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:

Swissprot:	Q9NZQ7
Gene ID:	29126
Storage Buffer:	Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:	Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:	CD274, also known as PD-L1 and B7-H1, is type I transmembrane glycoprotein that serves as a ligand for CD279 (PD-1). This interaction is believed to regulate the balance between the stimulatory and inhibitory signals needed for responses to microbes and maintenance of self-tolerance. CD274 is involved in the costimulation of T cell proliferation and IL-10 and IFN-γ production in an IL-2-dependent and CD279-independent manner. Conflicting data has shown that CD274 can inhibit T cell proliferation and cytokine production, and alternatively, enhance T cell activation. Other studies suggest that CD274 may signal bidirectionally, raising interesting implications for its expression in a wide variety of cell types, including T and B cells, antigen-presenting cells, and nonhematopoietic cells.

PerCP/Cyanine5.5 Anti-Human CD274/PD-L1 Antibody [29E.2A3] (AGEL2263)

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