Description

PerCP/Cyanine5.5 Anti-Mouse CD107a Antibody [1D4B]

The PerCP-Cyanine5.5 Anti-Mouse CD107a Antibody (1D4B) offered by AssayGenie is a high-quality monoclonal antibody specifically designed for research applications involving CD107a, a cell surface marker associated with cytotoxic activity. This antibody, suitable for use with mouse samples, is ideal for flow cytometry analysis and offers reliable and reproducible results. It efficiently binds to the CD107a protein, enabling precise detection and characterization in various cell populations, making it an excellent tool for immunology studies, particularly those focusing on cytotoxicity and immune cell degranulation.

CD107a, also known as LAMP-1, plays a crucial role in immune responses by being a marker of lysosomal exocytosis, a process central to cytotoxic granule release in immune cells. Its involvement in cytotoxic T cell and NK cell function makes it a key target for investigations in cancer immunotherapy, infectious diseases, and autoimmune disorders. Understanding the expression and function of CD107a can provide valuable insights into immune cell activation and effector mechanisms, contributing to the development of novel therapeutic strategies targeting immune modulation.

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Product Title:	PerCP/Cyanine5.5 Anti-Mouse CD107a Antibody [1D4B]
SKU:	AGEL3292
Size:	50 Tests, 100 Tests, 200 Tests
Clone No:	1D4B
Synonyms:	LAMP-1;Lysosome-associated membrane glycoprotein 1; lysosomal membrane glycoprotein 1; CD107 antigen-like family member A; lysosome-associated membrane protein 1;
Host Species:	Rat
Reactivity:	Mouse
Application:	FCM

Isotype:	Rat IgG2a, κ
Isotype Control:	PerCP/Cyanine5.5 Rat IgG2a, κ Isotype Control[2A3]
Form:	Liquid
Conjugation:	PerCP/Cyanine 5.5
Recommended Use:	Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:

Swissprot:	P11438
Gene ID:	16783
Storage Buffer:	Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:	Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:	The 1D4B antibody recognizes CD107a which is also known as, Lysosome-Associated Membrane Protein 1 (LAMP-1). CD107a is one of the two major glycoproteins in lysosome membranes that provide useful markers to distinguish lysosomes from other organelles. CD107a may play a role in the lysosomal degradation of certain molecules. Mouse CD107a is a type I transmembrane glycoprotein. It consists of a 40-kDa core protein which is heavily glycosylated to form heterogeneous mature glycoprotein of 110-140 kDa. It is principally expressed in epithelial cells and macrophages in a variety of organs. Following activation, CD107a is relocated to the surface of some lymphocytes, macrophages, epithelial cells, endothelial cells, platelets, and tumor cells. Cell-surface CD107a may participate in intercellular adhesion and adhesion to the extracellular matrix. Cell surface CD107a expression can serve as a useful marker for cytotoxic NK and CD8+ T cells, as well as, some malignant tumor cells.

PerCP/Cyanine5.5 Anti-Mouse CD107a Antibody [1D4B] (AGEL3292)

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