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Western blot analysis of extracts of various cell lines, using Pepsinogen II (PG II) Rabbit mAb (CAB22281) at1:2000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST.
Key Features

Pepsinogen II (PG II) Monoclonal Antibody (CAB22281)

Datasheet MSDS
SKU CAB22281
Product Type Antibody
Antibody Type Monoclonal Antibody
Reactivity Human, Mouse
Host Species Rabbit
Synonyms PEPC, PGII, Pepsinogen II (PG II)
$173 - $603

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Description

system_update_altDatasheetsystem_update_altMSDS

Pepsinogen II (PG II) Monoclonal Antibody (CAB22281)

The Pepsinogen II (PG II) Monoclonal Antibody (CAB22281) is a high-quality antibody developed for reliable detection and analysis of target proteins. This monoclonal antibody, developed through advanced techniques, is highly specific and reactive with human samples, making it ideal for studies in gastroenterology and related fields.Pepsinogen II is primarily produced in the stomach and plays a crucial role in the digestion process by aiding in the breakdown of proteins. Abnormal levels of pepsinogen II have been associated with various gastric conditions, including gastritis and gastric cancer, making it a valuable biomarker for diagnostic and research purposes.

This antibody is validated for use in IHC-P, ELISA applications and has demonstrated reactivity against Human, Mouse samples.

Product Name:Pepsinogen II (PG II) Monoclonal Antibody
SKU:CAB22281
Size:20μL, 100μL
Reactivity:Human, Mouse
Clone Number:ARC57719
Conjugate:Unconjugated
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:MKWM VVVL VCLQ LLEA AVVK VPLK KFKS IRET MKEK GLLG EFLR THKY DPAW KYRF GDLS VTYE PMAY MDAA YFGE ISIG TPPQ NFLV LFDT GSSN LWVP SVYC QSQA CTSH SRFN PSES STYS TNGQ TFSL QYGS GSLT GFFG YDTL TVQS IQVP NQEF GLSE NEPG TNFV YAQF DGIM GLAY PALS VDEA TTAM QGMV QEGA LTSP VFSV YLSN QQGS SGGA VVFG GVDS SLYT GQIY WAPV TQEL YWQI GIEE FLIG GQAS GWCS EGCQ AIVD TGTS LLTV PQQY MSAL LQAT GAQE DEYG QFLV NCNS IQNL PSLT FIIN GVEF PLPP SSYI LSNN GYCT VGVE PTYL SSQN GQPL WILG DVFL RSYY SVYD LGNN RVGF ATAA
Tested Applications:IHC-P ELISA
Recommended Dilution:
IHC-P1:5000 - 1:20000
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:PEPC, PGII, Pepsinogen II (PG II)
Cellular Localization:Secreted.
Calculated MW:42kDa
Observed MW:Refertofigures

This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1.

Purification MethodAffinity purification
Gene ID5225
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageImmunohistochemistry analysis of paraffin-embedded Human stomach tissue using Pepsinogen II (PG II) Rabbit mAb (CAB22281) at a dilution of 1:10000 (40x lens). High pressure antigen retrieval performed with 0.01M Tris-EDTA Buffer (pH 9.0) prior to IHC staining.
Product ImageImmunohistochemistry analysis of paraffin-embedded Mouse stomach tissue using Pepsinogen II (PG II) Rabbit mAb (CAB22281) at a dilution of 1:10000 (40x lens). High pressure antigen retrieval performed with 0.01M Tris-EDTA Buffer (pH 9.0) prior to IHC staining.
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