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Phospho-ATM-S1981 Rabbit Polyclonal Antibody (CABP0008)

SKU:
CABP0008
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Cycle
  • Cell Cycle Antibodies 2 Anti-Phospho-ATM-S1981 Antibody CABP0008
  • Cell Cycle Antibodies 2 Anti-Phospho-ATM-S1981 Antibody CABP0008
  • Cell Cycle Antibodies 2 Anti-Phospho-ATM-S1981 Antibody CABP0008
  • Cell Cycle Antibodies 2 Anti-Phospho-ATM-S1981 Antibody CABP0008
€419
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Description

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Product Name:Phospho-ATM-S1981 Rabbit Polyclonal Antibody
SKU:CABP0008
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse
Immunogen:A synthetic phosphorylated peptide around S1981 of human ATM (NP_000042.3).
Sequence:EGSQ S
Tested Applications:WB ELISA
Recommended Dilution:WB,1:500 - 1:1000
Synonyms:AT1; ATA; ATC; ATD; ATE; ATDC; TEL1; TELO1; Phospho-ATM-S1981
Positive Sample:293T,NIH/3T3
Conjugate:Unconjugated
Cellular Localization:Cytoplasmic vesicle, Nucleus.
Calculated MW:351kDa
Observed MW:370kDa

The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.

Purification Method:Affinity purification
Gene ID:472
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using (CABP0008) at 1:1000 dilution.293T cells were treated by Doxorubicin (0.5 uM) at 37℃ for 24 hours.293T cells were treated by UV at room temperature for 15-30 minutes.NIH/3T3 cells were treated by UV at room temperature for 15-30 minutes.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.

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