Phospho-ATR-S428 Monoclonal Antibody
- SKU:
- CABP1358
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Frequently bought together:
Description
| Product Name: | Phospho-ATR-S428 Monoclonal Antibody |
| Product Code: | CABP1358 |
| Reactivity: | Human |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC55118 |
| Reactivity: | Human |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:1000-1:5000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | 293T+UV |
| Cellular Location: | Chromosome, Nucleus, PML body |
The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also important for fragile site stability and centrosome duplication. Defects in this gene are a cause of Seckel syndrome 1.
| Immunogen: | A synthetic phosphorylated peptide around S428 of human ATR (NP_001175.2). |
| Sequence: | GISPK |
| Synonyms: | FRP1, MEC1, SCKL, FCTCS, SCKL1 |
| Calculated MW: | 301kDa |
| Observed MW: | 300kDa |
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