Anti-Phospho-CDC37-S13 Antibody (CABP1141)

SKU:
CABP1141
€99 - €389

Description

Technical Manual

Anti-Phospho-CDC37-S13 Antibody

Product Name:Anti-Phospho-CDC37-S13 Antibody
Product SKU:CABP1141
Size:20uL, 50 uL
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Background:

The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases. [provided by RefSeq, Jul 2008]

Immunogen:A phospho specific peptide corresponding to residues surrounding S13 of human CDC37
Sequence:

Email for sequence

Gene ID:11140
Swiss Prot:Q16543
Synonyms:P50CDC37
Calculated MW:50kDa
Observed MW:50KDa
Reactivity:Human, Mouse, Rat
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Application Key:Western blotting 
Positive Samples:293T, NIH/3T3, C6
Cellular Location:

Product Images

Anti-Phospho-CDC37-S13 Antibody (CABP1141)

Western blot - Phospho-CDC37-S13 Rabbit mAb (CABP1141)

Uniprot Information

UniProt Protein Function:CDC37: a molecular chaperone that functions in cell signal transduction. Forms complexes with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. Also interacts with androgen receptor. It is thought to play a critical role in directing Hsp90 to its target kinases.
UniProt Protein Details:

Protein type:Chaperone

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: protein complex; cytoplasm; cytosol

Molecular Function:protein kinase B binding; protein binding; chaperone binding; heat shock protein binding; unfolded protein binding; mitogen-activated protein kinase kinase kinase binding; Hsp90 protein binding; kinase binding

Biological Process: protein folding; protein stabilization; regulation of cyclin-dependent protein kinase activity; protein targeting

NCBI Summary:The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases. [provided by RefSeq, Jul 2008]
UniProt Code:Q16543
NCBI GenInfo Identifier:21542000
NCBI Gene ID:11140
NCBI Accession:Q16543.1
UniProt Secondary Accession:Q16543,Q53YA2,
UniProt Related Accession:Q16543
Molecular Weight:378
NCBI Full Name:Hsp90 co-chaperone Cdc37
NCBI Synonym Full Names:cell division cycle 37
NCBI Official Symbol:CDC37 
NCBI Official Synonym Symbols:P50CDC37 
NCBI Protein Information:hsp90 co-chaperone Cdc37; cell division cycle 37 homolog; CDC37 cell division cycle 37 homolog; hsp90 chaperone protein kinase-targeting subunit; CDC37 (cell division cycle 37, S. cerevisiae, homolog)
UniProt Protein Name:Hsp90 co-chaperone Cdc37
UniProt Synonym Protein Names:Hsp90 chaperone protein kinase-targeting subunit; p50Cdc37Hsp90 co-chaperone Cdc37, N-terminally processed
Protein Family:Hsp90 co-chaperone
UniProt Gene Name:CDC37 
UniProt Entry Name:CDC37_HUMAN
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Additional Information

Product type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Monoclonal Antibody
Research Area:
Cell Biology
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