The Phospho-CDKN1B/p27KIP1-T187 Antibody (CABP0328) is a high-quality antibody developed for reliable detection and analysis of target proteins. This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4). RRID AB_2770986 Gene ID 1027 Swiss Prot Synonym KIP1; MEN4; CDKN4; MEN1B; P27KIP1; Phospho-CDKN1B/p27KIP1-T187
This antibody is validated for use in WB applications and has demonstrated reactivity against Human samples.
Product Name:
Phospho-CDKN1B/p27KIP1-T187 Antibody
SKU:
CABP0328
Size:
100μL
Reactivity:
Human
Clone Number:
-
Conjugate:
Unconjugated
Immunogen:
Synthetic peptide. This information is considered to be commercially sensitive.
This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4). RRID AB_2770986 Gene ID 1027 Swiss Prot Synonym KIP1; MEN4; CDKN4; MEN1B; P27KIP1; Phospho-CDKN1B/p27KIP1-T187
Purification Method:
Affinity purification
Gene ID:
1027
RRID:
AB_2770986
Buffer Information:
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of lysates from HeLa cells, using Phospho-CDKN1B/p27KIP1-T187 Rabbit pAb (CABP0328). Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% BSA.
