Phospho-DNM1 (S778) Antibody (PACO02590)
- SKU:
- PACO02590
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
| Antibody Name: | Phospho-DNM1 (S778) Antibody |
| Antibody SKU: | PACO02590 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | WB:1:500-1:2000 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | synthesized peptide derived from human Dynamin I around the phosphorylation site of S778. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | DNM1; DNM; Dynamin-1 |
| UniProt Protein Function: | DYN1: a microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Concentrates within the presynaptic compartment and may participate in specialized neuronal functions such as rapid synaptic vesicle recycling. Part of a protein network that controls nucleation of actin from membranes. Contains one PH domain. |
| UniProt Protein Details: | Protein type:Microtubule-binding; Motility/polarity/chemotaxis; EC 3.6.5.5; Vesicle; Motor; Hydrolase Chromosomal Location of Human Ortholog: 9q34 Cellular Component: Golgi apparatus; membrane coat; microtubule; myelin sheath; photoreceptor inner segment; plasma membrane; synaptic vesicle Molecular Function:D2 dopamine receptor binding; GTP binding; GTPase activity; identical protein binding; nitric-oxide synthase binding; protein binding; protein C-terminus binding; protein complex binding; protein dimerization activity; protein kinase binding Biological Process: adult locomotory behavior; axon guidance; endocytosis; endosome organization and biogenesis; ephrin receptor signaling pathway; G-protein coupled receptor internalization; protein tetramerization; receptor-mediated endocytosis; sensory perception of sound; synaptic transmission, GABAergic Disease: Epileptic Encephalopathy, Early Infantile, 31 |
| NCBI Summary: | This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein possesses unique mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis and other vesicular trafficking processes. Actin and other cytoskeletal proteins act as binding partners for the encoded protein, which can also self-assemble leading to stimulation of GTPase activity. More than sixty highly conserved copies of the 3' region of this gene are found elsewhere in the genome, particularly on chromosomes Y and 15. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q05193 |
| NCBI GenInfo Identifier: | 172046078 |
| NCBI Gene ID: | 1759 |
| NCBI Accession: | Q05193.2 |
| UniProt Secondary Accession: | Q05193,Q5SYX0, Q5SYX2, Q6P3T6, Q86VD2, A6NLM6, |
| UniProt Related Accession: | Q05193 |
| Molecular Weight: | 95,895 Da |
| NCBI Full Name: | Dynamin-1 |
| NCBI Synonym Full Names: | dynamin 1 |
| NCBI Official Symbol: | DNM1 |
| NCBI Official Synonym Symbols: | DNM; EIEE31 |
| NCBI Protein Information: | dynamin-1 |
| UniProt Protein Name: | Dynamin-1 |
| Protein Family: | Dynamin |
| UniProt Gene Name: | DNM1 |
| UniProt Entry Name: | DYN1_HUMAN |
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