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Phospho-RASGRF1 (S916) Antibody (PACO03310)

SKU:
PACO03310
Product Type:
Antibody
Reactivity:
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IHC
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
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Description

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Antibody Name:Phospho-RASGRF1 (S916) Antibody
Antibody SKU:PACO03310
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, IHC, IF
Recommended Dilutions:IHC:1:100-1:300, IF:1:200-1:1000
Species Reactivity:Mouse, Rat
Immunogen:synthesized peptide derived from human Ras-GRF1 around the phosphorylation site of S916.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:RASGRF1; CDC25; GNRP; GRF1; Ras-specific guanine nucleotide-releasing factor 1; Ras-GRF1; Guanine nucleotide-releasing protein; GNRP; Ras-specific nucleotide exchange factor CDC25
UniProt Protein Function:RASGRF1: a guanine nucleotide exchange factor (GEF). Stimulates the dissociation of GDP from RAS protein. Activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit in the mouse brain,. The signaling pathway mediated by this protein may be important for long-term memory. Two alternatively spliced variants have been reported.Protein type: GEFs, Ras; GEFsChromosomal Location of Human Ortholog: 15q24.2Cellular Component: neuron projection; growth cone; plasma membrane; cytosolMolecular Function: glutamate receptor binding; Rho guanyl-nucleotide exchange factor activity; guanyl-nucleotide exchange factor activity; Ras guanyl-nucleotide exchange factor activityBiological Process: regulation of Ras protein signal transduction; synaptic transmission; regulation of Rac protein signal transduction; cell proliferation; long-term memory; small GTPase mediated signal transduction; regulation of synaptic plasticity; positive regulation of Ras protein signal transduction; signal transduction; neurite development; regulation of neuronal synaptic plasticity
UniProt Protein Details:
NCBI Summary:The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Mar 2009]
UniProt Code:P27671
NCBI GenInfo Identifier:24797099
NCBI Gene ID:5923
NCBI Accession:NP_002882.3
UniProt Secondary Accession:P27671,P27671
UniProt Related Accession:P27671,Q13972
Molecular Weight:143,218 Da
NCBI Full Name:ras-specific guanine nucleotide-releasing factor 1 isoform 1
NCBI Synonym Full Names:Ras protein-specific guanine nucleotide-releasing factor 1
NCBI Official Symbol:RASGRF1  
NCBI Official Synonym Symbols:GNRP; GRF1; CDC25; GRF55; CDC25L; H-GRF55; PP13187; ras-GRF1  
NCBI Protein Information:ras-specific guanine nucleotide-releasing factor 1; guanine nucleotide exchange factor; guanine nucleotide-releasing protein; guanine nucleotide-releasing factor, 55 kD; Ras-specific nucleotide exchange factor CDC25; Ras-specific guanine nucleotide-releas
UniProt Protein Name:Ras-specific guanine nucleotide-releasing factor 1
UniProt Synonym Protein Names:Guanine nucleotide-releasing protein; GNRP; Ras-specific nucleotide exchange factor CDC25
Protein Family:CDC25-like phosphatase
UniProt Gene Name:RASGRF1  
UniProt Entry Name:RGRF1_HUMAN

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