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Western blot analysis of extracts of various cell lines, using at 1:1000 dilution. C2C12 cells were treated by TGF-β (10 ng/ml) at 37℃ for 30 minutes. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
Key Features

Phospho-TAK1-S439 Monoclonal Antibody (CAB9437)

Datasheet MSDS
SKU CAB9437
Product Type Antibody
Antibody Type Monoclonal Antibody
Reactivity Mouse
Host Species Rabbit
Synonyms CSCF, FMD2, TAK1, MEKK7, TGF1a, Phospho-TAK1-S439
€131 - €457

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Description

system_update_altDatasheetsystem_update_altMSDS

Phospho-TAK1-S439 Monoclonal Antibody (CAB9437)

The Phospho-TAK1-S439 Monoclonal Antibody (CAB9437) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody is raised in rabbits and is highly specific to human samples, making it ideal for use in Western blot applications for the detection and analysis of phosphorylated TAK1 at serine 439.TAK1 is a crucial mediator in the activation of pro-inflammatory and anti-inflammatory pathways, making it a promising target for drug development in various diseases, including cancer, autoimmune disorders, and chronic inflammatory conditions.

This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Mouse samples.

Product Name:Phospho-TAK1-S439 Monoclonal Antibody
SKU:CAB9437
Size:20μL, 100μL
Reactivity:Mouse
Clone Number:ARC2714
Conjugate:Unconjugated
Immunogen:Synthetic peptide. This information is considered to be commercially sensitive.
Sequence:RRSI Q
Tested Applications:WB ELISA
Recommended Dilution:
WB1:500 - 1:1000
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:CSCF, FMD2, TAK1, MEKK7, TGF1a, Phospho-TAK1-S439
Positive Sample:C2C12 treated with TGF-β
Cellular Localization:Cell Membrane, Cytoplasm.
Calculated MW:67kDa
Observed MW:70-82kDa

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.

Purification MethodAffinity purification
Gene ID6885
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of various lysates using (CAB9437) at 1:1000 dilution. C2C12 cells were treated with TGF-β (10 ng/ml) at 37℃ for 30 minutes. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 90s.
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