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Anti-PI3 Kinase p110 beta Antibody (CAB0982)

SKU:
CAB0982
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Autophagy
  • Autophagy Antibodies Anti-PI3 Kinase p110 beta Antibody CAB0982
  • Autophagy Antibodies Anti-PI3 Kinase p110 beta Antibody CAB0982
  • Autophagy Antibodies Anti-PI3 Kinase p110 beta Antibody CAB0982
  • Autophagy Antibodies Anti-PI3 Kinase p110 beta Antibody CAB0982
$167 - $503
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Description

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Antibody Name:Anti-PI3 Kinase p110 beta Antibody
Antibody SKU:CAB0982
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 771-1070 of human PI3 Kinase p110 beta (NP_006210.1).
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:MCF7, Mouse brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 771-1070 of human PI3 Kinase p110 beta (NP_006210.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LYVE KCKY MDSK MKPL WLVY NNKV FGED SVGV IFKN GDDL RQDM LTLQ MLRL MDLL WKEA GLDL RMLP YGCL ATGD RSGL IEVV STSE TIAD IQLN SSNV AAAA AFNK DALL NWLK EYNS GDDL DRAI EEFT LSCA GYCV ASYV LGIG DRHS DNIM VKKT GQLF HIDF GHIL GNFK SKFG IKRE RVPF ILTY DFIH VIQQ GKTG NTEK FGRF RQCC EDAY LILR RHGN LFIT LFAL MLTA GLPE LTSV KDIQ YLKD SLAL GKSE EEAL KQFK QKFD EALR ESWT TKVN WMAH TVRK DYRS
Gene ID:5291
Uniprot:P42338
Cellular Location:Cytoplasm, Nucleus
Calculated MW:122kDa
Observed MW:123KDa
Synonyms:PIK3CB, P110BETA, PI3K, PI3KBETA, PIK3C1
Background:This gene encodes an isoform of the catalytic subunit of phosphoinositide 3-kinase (PI3K). These kinases are important in signaling pathways involving receptors on the outer membrane of eukaryotic cells and are named for their catalytic subunit. The encoded protein is the catalytic subunit for PI3Kbeta (PI3KB). PI3KB has been shown to be part of the activation pathway in neutrophils which have bound immune complexes at sites of injury or infection. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:PIK3CB: catalytic subunit of phosphoinositide-3-kinase beta. Catalyzes the production of phosphatidylinositol-3,4,5-triphosphate by phosphorylating phosphatidylinositol (PI), phosphatidylinositol-4-phosphate (PIP) and phosphatidylinositol-4,5-bisphosphate (PIP2). Growth factors and hormones trigger this phosphorylation event, which in turn coordinates cell growth, cell cycle entry, cell migration and cell survival. PTEN reverses this process, and the PI3K signaling pathway is constitutively activated in human cancers that have loss of function of PTEN. Expressed ubiquitously.
UniProt Protein Details:

Protein type:Carbohydrate Metabolism - inositol phosphate; Motility/polarity/chemotaxis; EC 2.7.1.153; Kinase, lipid

Chromosomal Location of Human Ortholog: 3q22.3

Cellular Component: cytosol; intercellular bridge; nucleolus; nucleus; phosphoinositide 3-kinase complex; plasma membrane

Molecular Function:1-phosphatidylinositol-3-kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; phosphatidylinositol-4-phosphate 3-kinase activity; phosphoinositide 3-kinase activity; protein binding

Biological Process: activation of MAPK activity; cell migration; chemotaxis; G-protein coupled receptor protein signaling pathway; leukocyte migration; phosphatidylinositol biosynthetic process; phosphoinositide 3-kinase cascade; phosphoinositide-mediated signaling; platelet activation; positive regulation of autophagy; regulation of cell-matrix adhesion; regulation of phosphoinositide 3-kinase cascade; T cell receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway; vascular endothelial growth factor receptor signaling pathway

NCBI Summary:This gene encodes an isoform of the catalytic subunit of phosphoinositide 3-kinase (PI3K). These kinases are important in signaling pathways involving receptors on the outer membrane of eukaryotic cells and are named for their catalytic subunit. The encoded protein is the catalytic subunit for PI3Kbeta (PI3KB). PI3KB has been shown to be part of the activation pathway in neutrophils which have bound immune complexes at sites of injury or infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]
UniProt Code:P42338
NCBI GenInfo Identifier:1171955
NCBI Gene ID:5291
NCBI Accession:P42338.1
UniProt Secondary Accession:P42338,Q24JU2, D3DNF0,
UniProt Related Accession:P42338
Molecular Weight:122,762 Da
NCBI Full Name:Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
NCBI Synonym Full Names:phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
NCBI Official Symbol:PIK3CB  
NCBI Official Synonym Symbols:PI3K; PIK3C1; P110BETA; PI3KBETA  
NCBI Protein Information:phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
UniProt Protein Name:Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
UniProt Synonym Protein Names:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta; PtdIns-3-kinase subunit p110-beta; p110beta
Protein Family:Phosphatidylinositol 4,5-bisphosphate 3-kinase
UniProt Gene Name:PIK3CB  
UniProt Entry Name:PK3CB_HUMAN
Anti-PI3 Kinase p110 beta Antibody (CAB0982)Western blot analysis of extracts of various cell lines, using PI3 Kinase p110 beta Rabbit pAb (CAB0982) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Anti-PI3 Kinase p110 beta Antibody (CAB0982)Immunohistochemistry of paraffin-embedded mouse lung using PI3 Kinase p110 beta antibody (CAB0982) at dilution of 1:100 (40x lens).
Anti-PI3 Kinase p110 beta Antibody (CAB0982)Immunohistochemistry of paraffin-embedded human lung using PI3 Kinase p110 beta antibody (CAB0982) at dilution of 1:100 (40x lens).
Anti-PI3 Kinase p110 beta Antibody (CAB0982)Immunohistochemistry of paraffin-embedded human colon carcinoma using PI3 Kinase p110 beta antibody (CAB0982) at dilution of 1:100 (40x lens).

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