PLN Rabbit Polyclonal Antibody (CAB17964)
- SKU:
- CAB17964
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | PLN Rabbit Polyclonal Antibody |
SKU: | CAB17964 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-52 of human PLN (NP_002658.1). |
Sequence: | MEKV QYLT RSAI RRAS TIEM PQQA RQKL QNLF INFC LILI CLLL ICII VMLL |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:100 - 1:500 |
Synonyms: | PLB; CMD1P; CMH18; PLN |
Positive Sample: | Mouse heart,Rat heart |
Cellular Localization: | endoplasmic reticulum, mitochondrial membrane, mitochondrion, perinuclear region of cytoplasm |
Calculated MW: | 6kDa |
Observed MW: | 6kDa |
The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy.
Purification Method: | Affinity purification |
Gene ID: | 5350 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |