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Anti-PMPCB Antibody (CAB4312)

SKU:
CAB4312
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
  • Cell Biology Antibodies 9 Anti-PMPCB Antibody CAB4312
  • Cell Biology Antibodies 9 Anti-PMPCB Antibody CAB4312
  • Cell Biology Antibodies 9 Anti-PMPCB Antibody CAB4312
  • Cell Biology Antibodies 9 Anti-PMPCB Antibody CAB4312
€139 - €419
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Description

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Antibody Name:Anti-PMPCB Antibody
Antibody SKU:CAB4312
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 110-380 of human PMPCB (NP_004270.2).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:LO2, MCF7, HT-1080, Mouse liver, Mouse kidney, Mouse heart
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 110-380 of human PMPCB (NP_004270.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:GTKK RSQL DLEL EIEN MGAH LNAY TSRE QTVY YAKA FSKD LPRA VEIL ADII QNST LGEA EIER ERGV ILRE MQEV ETNL QEVV FDYL HATA YQNT ALGR TILG PTEN IKSI SRKD LVDY ITTH YKGP RIVL AAAG GVSH DELL DLAK FHFG DSLC THKG EIPA LPPC KFTG SEIR VRDD KMPL AHLA IAVE AVGW AHPD TICL MVAN TLIG NWDR SFGG GMNL SSKL AQLT CHGN LCHS FQSF NTSY TDTG LWGL YMVC ESST VADM LHV
Gene ID:9512
Uniprot:O75439
Cellular Location:Mitochondrion matrix
Calculated MW:54kDa
Observed MW:50kDa
Synonyms:PMPCB, Beta-MPP, MPP11, MPPB, MPPP52, P-52
Background:This gene is a member of the peptidase M16 family and encodes a protein with a zinc-binding motif. This protein is located in the mitochondrial matrix and catalyzes the cleavage of the leader peptides of precursor proteins newly imported into the mitochondria, though it only functions as part of a heterodimeric complex.
UniProt Protein Function:PMPCB: Cleaves presequences (transit peptides) from mitochondrial protein precursors. Belongs to the peptidase M16 family.
UniProt Protein Details:

Protein type:Mitochondrial; Protease; EC 3.4.24.64

Chromosomal Location of Human Ortholog: 7q22.1

Cellular Component: mitochondrial matrix; mitochondrial inner membrane

Molecular Function:metal ion binding; metalloendopeptidase activity

Biological Process: cellular protein metabolic process; proteolysis; protein targeting to mitochondrion

NCBI Summary:This gene is a member of the peptidase M16 family and encodes a protein with a zinc-binding motif. This protein is located in the mitochondrial matrix and catalyzes the cleavage of the leader peptides of precursor proteins newly imported into the mitochondria, though it only functions as part of a heterodimeric complex. [provided by RefSeq, Jul 2008]
UniProt Code:O75439
NCBI GenInfo Identifier:29840827
NCBI Gene ID:9512
NCBI Accession:O75439.2
UniProt Secondary Accession:O75439,O60416, Q96FV4,
UniProt Related Accession:O75439
Molecular Weight:489
NCBI Full Name:Mitochondrial-processing peptidase subunit beta
NCBI Synonym Full Names:peptidase (mitochondrial processing) beta
NCBI Official Symbol:PMPCB  
NCBI Official Synonym Symbols:MPPB; P-52; MPP11; MPPP52; Beta-MPP  
NCBI Protein Information:mitochondrial-processing peptidase subunit beta; mitochondrial processing peptidase beta subunit
UniProt Protein Name:Mitochondrial-processing peptidase subunit beta
UniProt Synonym Protein Names:Beta-MPP; P-52
UniProt Gene Name:PMPCB  
UniProt Entry Name:MPPB_HUMAN
Anti-PMPCB Antibody (CAB4312)Western blot analysis of extracts of various cell lines, using PMPCB antibody (CAB4312) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Anti-PMPCB Antibody (CAB4312)Immunohistochemistry of paraffin-embedded human stomach using PMPCB antibody (CAB4312) at dilution of 1:100 (40x lens).
Anti-PMPCB Antibody (CAB4312)Immunohistochemistry of paraffin-embedded rat kidney using PMPCB antibody (CAB4312) at dilution of 1:100 (40x lens).
Anti-PMPCB Antibody (CAB4312)Immunohistochemistry of paraffin-embedded human colon carcinoma using PMPCB antibody (CAB4312) at dilution of 1:100 (40x lens).

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