The POMP Antibody (CAB9067) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.POMP is essential for the maturation of the 20S core particle of the proteasome, the cellular machinery responsible for degrading damaged or unwanted proteins. Dysregulation of POMP has been linked to various diseases, including neurodegenerative disorders and cancer. By targeting the POMP protein, researchers can better understand the mechanisms underlying protein degradation and potentially develop novel therapeutic strategies for these conditions.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human samples.
Product Name:
POMP Antibody
SKU:
CAB9067
Size:
20μL, 100μL
Reactivity:
Human
Conjugate:
Unconjugated
Immunogen:
Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:
UMP1, PRAAS2, HSPC014, C13orf12, PNAS-110, POMP
Positive Sample:
HeLa, HepG2, Jurkat
Cellular Localization:
Cytoplasm, Microsome Membrane, Nucleus, Cytosol.
Calculated MW:
16kDa
Observed MW:
16kDa
The protein encoded by this gene is a molecular chaperone that binds 20S preproteasome components and is essential for 20S proteasome formation. The 20S proteasome is the proteolytically active component of the 26S proteasome complex. The encoded protein is degraded before the maturation of the 20S proteasome is complete. A variant in the 5' UTR of this gene has been associated with KLICK syndrome, a rare skin disorder.
Purification Method
Affinity purification
Gene ID
51371
RRID
AB_2771748
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using POMP Rabbit pAb (CAB9067) at 1:3000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (AbGn00021). Exposure time: 90s.
