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Anti-PPP1R9B Antibody (CAB17230)

SKU:
CAB17230
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Developmental Biology
  • Developmental Biology Anti-PPP1R9B Antibody CAB17230
  • Developmental Biology Anti-PPP1R9B Antibody CAB17230
€139 - €419
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Description

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Antibody Name:Anti-PPP1R9B Antibody
Antibody SKU:CAB17230
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthetic peptide of human PPP1R9B.
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:U-87MG, K-562, Mouse brain
Immunogen:A synthetic peptide of human PPP1R9B.
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:84687
Uniprot:Q96SB3
Cellular Location:
Calculated MW:89kDa
Observed MW:127kDa
Synonyms:PPP1R9B, PPP1R6, PPP1R9, SPINO, Spn
Background:This gene encodes a scaffold protein that functions as a regulatory subunit of protein phosphatase 1a. Expression of this gene is particularly high in dendritic spines, suggesting that the encoded protein may play a role in receiving signals from the central nervous system. The encoded protein has putative tumor suppressor function and decreased expression has been observed in tumors.
UniProt Protein Function:Spinophilin: actin-binding regulatory subunit of protein phosphatase 1 (PP1). The actin-binding domain of spinophilin is necessary and sufficient for targeting of spinophilin to dendrites and dendritic spines. May play a role in establishing a signaling complex for dopaminergic neurotransmission through D2 receptors by linking receptors downstream signaling molecules and the actin cytoskeleton. Interacts with p14-ARF. Contains one PDZ/DHR domain.
UniProt Protein Details:

Protein type:Protein phosphatase, regulatory subunit; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 17q21.33

Cellular Component: nucleoplasm; cortical actin cytoskeleton; adherens junction; lamellipodium; cytoplasm; dendritic spine; plasma membrane; synapse; protein phosphatase type 1 complex; filopodium

Molecular Function:protein binding; protein phosphatase inhibitor activity; actin binding; protein phosphatase 1 binding

Biological Process: regulation of synaptic transmission; regulation of protein amino acid phosphorylation; cell migration; regulation of cell growth by extracellular stimulus; filopodium formation; RNA splicing; regulation of exit from mitosis; calcium-mediated signaling; actin filament organization; regulation of cell proliferation; negative regulation of catalytic activity; dendrite development; negative regulation of cell growth; cell cycle arrest

NCBI Summary:This gene encodes a scaffold protein that functions as a regulatory subunit of protein phosphatase 1a. Expression of this gene is particularly high in dendritic spines, suggesting that the encoded protein may play a role in receiving signals from the central nervous system. The encoded protein has putative tumor suppressor function and decreased expression has been observed in tumors. [provided by RefSeq, Feb 2014]
UniProt Code:Q96SB3
NCBI GenInfo Identifier:90101416
NCBI Gene ID:84687
NCBI Accession:Q96SB3.2
UniProt Secondary Accession:Q96SB3,Q8TCR9,
UniProt Related Accession:Q96SB3
Molecular Weight:815
NCBI Full Name:Neurabin-2
NCBI Synonym Full Names:protein phosphatase 1, regulatory subunit 9B
NCBI Official Symbol:PPP1R9B  
NCBI Official Synonym Symbols:Spn; SPINO; PPP1R6; PPP1R9  
NCBI Protein Information:neurabin-2; neurabin-II; protein phosphatase 1, regulatory (inhibitor) subunit 9B; protein phosphatase 1, regulatory subunit 9B, spinophilin
UniProt Protein Name:Neurabin-2
UniProt Synonym Protein Names:Neurabin-II; Protein phosphatase 1 regulatory subunit 9B; Spinophilin
UniProt Gene Name:PPP1R9B  
UniProt Entry Name:NEB2_HUMAN
Anti-PPP1R9B Antibody (CAB17230)Western blot analysis of extracts of various cell lines, using PPP1R9B antibody (CAB17230) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 3min.
Anti-PPP1R9B Antibody (CAB17230)Immunofluorescence analysis of L929 cells using PPP1R9B antibody (CAB17230) at dilution of 1:100. Blue: DAPI for nuclear staining.

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