Anti-PRKRA Antibody (CAB8779)

Antibody Name:	Anti-PRKRA Antibody
Antibody SKU:	CAB8779
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IHC
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	A synthesized peptide derived from human PRKRA

Application:	WB IHC
Recommended Dilution:	WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:	Human, Mouse, Rat
Positive Samples:	293T, PC-12, Mouse testis

Immunogen:	A synthesized peptide derived from human PRKRA
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	Email for sequence
Gene ID:	8575
Uniprot:	O75569
Cellular Location:
Calculated MW:	34kDa
Observed MW:	34KDa

Synonyms:	DYT16, HSD14, PACT, RAX
Background:	This gene encodes a protein kinase activated by double-stranded RNA which mediates the effects of interferon in response to viral infection. Mutations in this gene have been associated with dystonia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]

UniProt Protein Function:	PACT: a double strand RNA binding protein (dsRBP). Interacts with TRBP and Dicer to stimulate the cleavage of double-stranded or short hairpin RNA to siRNA. Appears to have a pro-apoptotic function that may be suppressed in the presence of growth factor. Activates the interferon-induced protein kinase PKR. Three alternatively spliced human isoforms have been reported.
UniProt Protein Details:	Protein type:Activator; RNA-binding; RNA processing Chromosomal Location of Human Ortholog: 2q31.2 Cellular Component: nucleoplasm; membrane; perinuclear region of cytoplasm; cytoplasm; cytosol Molecular Function:protein binding; protein homodimerization activity; enzyme activator activity Biological Process: positive regulation of catalytic activity; negative regulation of cell proliferation; skeletal morphogenesis; response to virus; outer ear morphogenesis; immune response; gene expression; middle ear morphogenesis; RNA interference, production of siRNA; protein amino acid phosphorylation Disease: Dystonia 16
NCBI Summary:	This gene encodes a protein kinase activated by double-stranded RNA which mediates the effects of interferon in response to viral infection. Mutations in this gene have been associated with dystonia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]
UniProt Code:	O75569
NCBI GenInfo Identifier:	74735517
NCBI Gene ID:	8575
NCBI Accession:	O75569.1
UniProt Secondary Accession:	O75569,Q53G24, Q6X7T5, Q8NDK4, A8K3I6,
UniProt Related Accession:	O75569
Molecular Weight:	313
NCBI Full Name:	Interferon-inducible double-stranded RNA-dependent protein kinase activator A
NCBI Synonym Full Names:	protein kinase, interferon-inducible double stranded RNA dependent activator
NCBI Official Symbol:	PRKRA
NCBI Official Synonym Symbols:	RAX; PACT; DYT16; HSD14
NCBI Protein Information:	interferon-inducible double-stranded RNA-dependent protein kinase activator A; PKR-associated protein X; PKR-associating protein X; protein activator of the interferon-induced protein kinase; protein kinase, interferon-inducible double stranded RNA-dependent activator; protein kinase, interferon-inducible double-stranded RNA-dependent activator; interferon-inducible double stranded RNA-dependent protein kinase activator A
UniProt Protein Name:	Interferon-inducible double-stranded RNA-dependent protein kinase activator A
UniProt Synonym Protein Names:	PKR-associated protein X; PKR-associating protein X; Protein activator of the interferon-induced protein kinase; Protein kinase, interferon-inducible double-stranded RNA-dependent activator
Protein Family:	Interferon-inducible double-stranded RNA-dependent protein kinase activator
UniProt Gene Name:	PRKRA
UniProt Entry Name:	PRKRA_HUMAN

Western blot - PRKRA Rabbit mAb (CAB8779)

Antibodies

Anti-PRKRA Antibody (CAB5417)

PRKRA Antibody (PACO11481)

Secondary Antibody

Anti-HRP Goat Anti-Mouse IgG (H+L) Antibody (CABS003)