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JARID2 Rabbit Polyclonal Antibody (CAB9823)

SKU:
CAB9823
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Developmental Biology
€139 - €419
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Description

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Product Name:JARID2 Rabbit Polyclonal Antibody
SKU:CAB9823
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1027-1246 of human JARID2 (NP_004964.2).
Sequence:ETVH FATT QWTS MGFE TAKE MKRR HIAK PFSM EKLL YQIA QAEA KKEN GPTL STIS ALLD ELRD TELR QRRQ LFEA GLHS SARY GSHD GSST VADG KKKP RKWL QLET SERR CQIC QHLC YLSM VVQE NENV VFCL ECAL RHVE KQKS CRGL KLMY RYDE EQII SLVN QICG KVSG KNGS IENC LSKP TPKR GPRK RATV DVPP SRLS ASSS SKSA SSSS
Tested Applications:WB ELISA
Recommended Dilution:WB,1:500 - 1:2000
Synonyms:JMJ; DIDDF; JARID2
Positive Sample:HL-60,Mouse thymus,Rat heart
Conjugate:Unconjugated
Cellular Localization:Nucleus.
Calculated MW:139kDa
Observed MW:160kDa

This gene encodes a Jumonji- and AT-rich interaction domain (ARID)-domain-containing protein. The encoded protein is a DNA-binding protein that functions as a transcriptional repressor. This protein interacts with the Polycomb repressive complex 2 (PRC2) which plays an essential role in regulating gene expression during embryonic development. This protein facilitates the recruitment of the PRC2 complex to target genes. Alternate splicing results in multiple transcript variants. Mutations in this gene are associated with chronic myeloid malignancies.

Purification Method:Affinity purification
Gene ID:3720
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Product ImageWestern blot analysis of extracts of various cell lines, using JARID2 antibody (CAB9823) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.

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