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Anti-QKI Antibody (CAB7043)

SKU:
CAB7043
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Developmental Biology
  • Developmental Biology Anti-QKI Antibody CAB7043
  • Developmental Biology Anti-QKI Antibody CAB7043
  • Developmental Biology Anti-QKI Antibody CAB7043
  • Developmental Biology Anti-QKI Antibody CAB7043
€139 - €419
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Description

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Antibody Name:Anti-QKI Antibody
Antibody SKU:CAB7043
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-341 of human QKI (NP_006766.1).
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HL-60, HeLa, NCI-H460, Mouse heart, Mouse lung, Mouse brain, Rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-341 of human QKI (NP_006766.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MVGE METK EKPK PTPD YLMQ LMND KKLM SSLP NFCG IFNH LERL LDEE ISRV RKDM YNDT LNGS TEKR SAEL PDAV GPIV QLQE KLYV PVKE YPDF NFVG RILG PRGL TAKQ LEAE TGCK IMVR GKGS MRDK KKEE QNRG KPNW EHLN EDLH VLIT VEDA QNRA EIKL KRAV EEVK KLLV PAAE GEDS LKKM QLME LAIL NGTY RDAN IKSP ALAF SLAA TAQA APRI ITGP APVL PPAA LRTP TPAG PTIM PLIR QIQT AVMP NGTP HPTA AIVP PGPE AGLI YTPY EYPY TLAP ATSI LEYP IEPS GVLG AVAT KVRR HDMR VHPY QRIV TADR AATG N
Gene ID:9444
Uniprot:Q96PU8
Cellular Location:Cytoplasm, Nucleus
Calculated MW:35kDa/36kDa/37kDa
Observed MW:38kDa
Synonyms:QKI, Hqk, QK, QK1, QK3, hqkI
Background:The protein encoded by this gene is an RNA-binding protein that regulates pre-mRNA splicing, export of mRNAs from the nucleus, protein translation, and mRNA stability. The encoded protein is involved in myelinization and oligodendrocyte differentiation and may play a role in schizophrenia. Multiple transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:RNA-binding protein that plays a central role in myelinization (PubMed:16641098). Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Regulates target mRNA stability (PubMed:23630077). In addition, acts by regulating pre-mRNA splicing, mRNA export and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia (PubMed:16641098). Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor.
NCBI Summary:The protein encoded by this gene is an RNA-binding protein that regulates pre-mRNA splicing, export of mRNAs from the nucleus, protein translation, and mRNA stability. The encoded protein is involved in myelinization and oligodendrocyte differentiation and may play a role in schizophrenia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
UniProt Code:Q96PU8
NCBI GenInfo Identifier:74761039
NCBI Gene ID:9444
NCBI Accession:Q96PU8.1
UniProt Secondary Accession:Q96PU8,Q2I375, Q5MJQ1, Q969L9, Q96EJ3, Q96KA3, Q96PU6 Q96PU7, Q9P0X6, Q9P0X7, Q9P0X8, Q9P0X9,
UniProt Related Accession:Q96PU8
Molecular Weight:35,131 Da
NCBI Full Name:Protein quaking
NCBI Synonym Full Names:QKI, KH domain containing RNA binding
NCBI Official Symbol:QKI  
NCBI Official Synonym Symbols:QK; Hqk; QK1; QK3; hqkI  
NCBI Protein Information:protein quaking
UniProt Protein Name:Protein quaking
Protein Family:Protein quaking
UniProt Gene Name:QKI  
UniProt Entry Name:QKI_HUMAN
Anti-QKI Antibody (CAB7043)Western blot analysis of extracts of various cell lines, using QKI antibody (CAB7043) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 30s.
Anti-QKI Antibody (CAB7043)Western blot analysis of extracts of various cell lines, using QKI antibody (CAB7043) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Anti-QKI Antibody (CAB7043)Immunohistochemistry of paraffin-embedded mouse brain using QKI antibody (CAB7043) at dilution of 1:100 (40x lens).
Anti-QKI Antibody (CAB7043)Immunofluorescence analysis of MCF7 cells using QKI antibody (CAB7043).

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