UniProt Protein Function: | PSD: Guanine nucleotide exchange factor for ARF6. Induces cytoskeletal remodeling. Belongs to the PSD family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: GEFs; GEFs, ARFChromosomal Location of Human Ortholog: 10q24Cellular Component: ruffle; integral to membrane; plasma membrane; trans-Golgi network; cell junctionMolecular Function: signal transducer activity; protein binding; phospholipid binding; ARF guanyl-nucleotide exchange factor activityBiological Process: vesicle-mediated transport; neuron differentiation; regulation of ARF protein signal transduction; signal transduction; positive regulation of GTPase activity |
UniProt Protein Details: | |
NCBI Summary: | This gene encodes a Plekstrin homology and SEC7 domains-containing protein that functions as a guanine nucleotide exchange factor. The encoded protein regulates signal transduction by activating ADP-ribosylation factor 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012] |
UniProt Code: | A5PKW4 |
NCBI GenInfo Identifier: | 402534559 |
NCBI Gene ID: | 5662 |
NCBI Accession: | NP_001257894.1 |
UniProt Secondary Accession: | A5PKW4,Q15673, Q8IVG0, B1AKX7, D3DR87 |
UniProt Related Accession: | A5PKW4 |
Molecular Weight: | 70,393 Da |
NCBI Full Name: | PH and SEC7 domain-containing protein 1 isoform 1 |
NCBI Synonym Full Names: | pleckstrin and Sec7 domain containing |
NCBI Official Symbol: | PSDÂ Â |
NCBI Official Synonym Symbols: | TYL; EFA6; PSD1; EFA6AÂ Â |
NCBI Protein Information: | PH and SEC7 domain-containing protein 1 |
UniProt Protein Name: | PH and SEC7 domain-containing protein 1 |
UniProt Synonym Protein Names: | Exchange factor for ARF6; Pleckstrin homology and SEC7 domain-containing protein 1 |
Protein Family: | PH and SEC7 domain-containing protein |
UniProt Gene Name: | PSDÂ Â |
UniProt Entry Name: | PSD1_HUMAN |