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Anti-PTPN4 Antibody (CAB4061)

SKU:
CAB4061
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
€139 - €419
Frequently bought together:

Description

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Antibody Name:Anti-PTPN4 Antibody
Antibody SKU:CAB4061
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human PTPN4 (NP_002821.1).
Application:WB
Recommended Dilution:WB 1:200 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:SH-SY5Y, K-562, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human PTPN4 (NP_002821.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MTSR FRLP AGRT YNVR ASEL ARDR QHTE VVCN ILLL DNTV QAFK VNKH DQGQ VLLD VVFK HLDL TEQD YFGL QLAD DSTD NPRW LDPN KPIR KQLK RGSP YSLN FRVK FFVS DPNK LQEE YTRY QYFL QIKQ DILT GRLP CPSN TAAL LASF AVQS ELGD YDQS ENLS GYLS DYSF IPNQ PQDF EKEI AKLH QQHI GLSP AEAE FNYL NTAR TLEL YGVE FHYA RDQS NNEI MIGV MSGG
Gene ID:5775
Uniprot:P29074
Cellular Location:Cell membrane, Cytoplasm, Cytoplasmic side, Peripheral membrane protein, cytoskeleton
Calculated MW:105kDa
Observed MW:115kDa
Synonyms:PTPN4, MEG, PTPMEG, PTPMEG1
Background:The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. This PTP has been shown to interact with glutamate receptor delta 2 and epsilon subunits, and is thought to play a role in signalling downstream of the glutamate receptors through tyrosine dephosphorylation.
UniProt Protein Function:PTPN4: May act at junctions between the membrane and the cytoskeleton. Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
UniProt Protein Details:

Protein type:Protein phosphatase, tyrosine (non-receptor); Motility/polarity/chemotaxis; EC 3.1.3.48

Chromosomal Location of Human Ortholog: 2q14.2

Cellular Component: internal side of plasma membrane; cytoskeleton; cytoplasm

Molecular Function:protein binding; cytoskeletal protein binding; non-membrane spanning protein tyrosine phosphatase activity

Biological Process: protein amino acid dephosphorylation

NCBI Summary:The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. This PTP has been shown to interact with glutamate receptor delta 2 and epsilon subunits, and is thought to play a role in signalling downstream of the glutamate receptors through tyrosine dephosphorylation. [provided by RefSeq, Jul 2008]
UniProt Code:P29074
NCBI GenInfo Identifier:131531
NCBI Gene ID:5775
NCBI Accession:P29074.1
UniProt Secondary Accession:P29074,Q9UDA7, B2RBV8,
UniProt Related Accession:P29074
Molecular Weight:926
NCBI Full Name:Tyrosine-protein phosphatase non-receptor type 4
NCBI Synonym Full Names:protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
NCBI Official Symbol:PTPN4  
NCBI Official Synonym Symbols:MEG; PTPMEG; PTPMEG1  
NCBI Protein Information:tyrosine-protein phosphatase non-receptor type 4; PTPase-MEG1; megakaryocyte phosphatase; protein tyrosine phosphatase MEG1; protein-tyrosine phosphatase MEG1; megakaryocyte protein-tyrosine phosphatase
UniProt Protein Name:Tyrosine-protein phosphatase non-receptor type 4
UniProt Synonym Protein Names:Protein-tyrosine phosphatase MEG1; MEG; PTPase-MEG1
Protein Family:Tyrosine-protein phosphatase non-receptor
UniProt Gene Name:PTPN4  
UniProt Entry Name:PTN4_HUMAN
Anti-PTPN4 Antibody (CAB4061)Western blot analysis of extracts of various cell lines, using PTPN4 antibody (CAB4061) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s.

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