The Purified Human CD279 (PD-1) Monoclonal Antibody (J116) - AGEL1607 is a specialized tool for researchers studying immune checkpoints and their role in immune regulation. This monoclonal antibody targets the CD279 (PD-1) protein, a key checkpoint receptor involved in the regulation of T cell activity and tolerance.The PD-1 protein is known for its role in suppressing T cell responses, preventing overactivation of the immune system and maintaining immune homeostasis. By binding specifically to PD-1, this antibody allows for the detection and analysis of PD-1 expression in human samples, providing valuable insights into immune response pathways and potential therapeutic targets.Validated for use in various applications, including flow cytometry and immunohistochemistry, this monoclonal antibody offers researchers a reliable tool for investigating the function and expression of PD-1 in different cell types and disease contexts.
Its high specificity and sensitivity make it ideal for studies in immunology, cancer research, and the development of immunotherapies targeting the PD-1 pathway.By enabling detailed analysis of PD-1 expression and function, the Purified Human CD279 (PD-1) Monoclonal Antibody (J116) - AGEL1607 facilitates research aimed at understanding and manipulating immune checkpoints for the treatment of cancer, autoimmune diseases, and other immune-related disorders. Unlock the potential of immune checkpoint modulation with this advanced research tool.
Product Title:
Purified Anti-Human CD279/PD-1 Antibody [J116]
SKU:
AGEL1607
Size:
25µg, 100µg
Clone No:
J116
Synonyms:
PD-1; Programmed Death-1;
Host Species:
Mouse
Reactivity:
Human
Application:
FCM
Isotype:
Mouse IgG1, κ
Isotype Control:
Purified Mouse IgG1, κ Isotype Control[MOPC-21]
Form:
Liquid
Conjugation:
Unconjugated
Recommended Use:
Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:
Programmed cell death 1 (PD-1), also known as CD279, is a 55 kD member of the immunoglobulin superfamily. CD279 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region and plays a key role in peripheral tolerance and autoimmune disease. CD279 is expressed predominantly on activated T cells, B cells, and myeloid cells. PD-L1 (B7-H1) and PD-L2 (B7-DC) are ligands of CD279 (PD-1) and are members of the B7 gene family. Evidence suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Interaction of CD279 ligands results in inhibition of T cell proliferation and cytokine secretion.
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