Description

Purified Anti-Human CD279/PD-1 Antibody [J110]

The Purified Anti-Human CD279 (PD-1) Antibody J110 is a cutting-edge tool for researchers studying immune checkpoint molecules in the context of immunotherapy and cancer research. This monoclonal antibody specifically targets CD279 (PD-1), a crucial regulator of T cell activation and tolerance.Developed using advanced purification techniques, this antibody offers high specificity and sensitivity in detecting human CD279 (PD-1) protein expression. It is validated for use in various applications including flow cytometry, immunohistochemistry, and immunofluorescence, providing researchers with versatile options for elucidating the role of CD279 in immune responses and tumor evasion mechanisms.

CD279 (PD-1) has emerged as a key target for novel cancer therapies, as its interaction with ligands such as PD-L1 can suppress anti-tumor immune responses. By utilizing this antibody, researchers can investigate the expression levels and localization of CD279 in tumor microenvironments, paving the way for the development of more effective immunotherapeutic strategies.For researchers seeking to unravel the complexities of immune checkpoint pathways and explore innovative treatment modalities in oncology, the Purified Anti-Human CD279 (PD-1) Antibody J110 represents a valuable ally in advancing scientific understanding and clinical outcomes.

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Product Title:	Purified Anti-Human CD279/PD-1 Antibody [J110]
SKU:	AGEL2401
Size:	25µg, 100µg
Clone No:	J110
Synonyms:	PDCD1;PD1;Protein PD-1;hPD-1;
Host Species:	Mouse
Reactivity:	Human
Application:	FCM

Isotype:	Mouse IgG1, κ
Isotype Control:	Purified Mouse IgG1, κ Isotype Control[MOPC-21]
Form:	Liquid
Conjugation:	Unconjugated
Recommended Use:	Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 2.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Swissprot:	Q15116
Gene ID:	3683
Storage Buffer:	Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer.
Stability & Storage:	Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:	Programmed cell death 1 (PD-1), also known as CD279, is a 55 kD member of the immunoglobulin superfamily. CD279 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region and plays a key role in peripheral tolerance and autoimmune disease. CD279 is expressed predominantly on activated T cells, B cells, and myeloid cells. PD-L1 and PD-L2 are ligands of CD279 (PD-1) and are members of the B7 gene family. Evidence suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Interaction of CD279 ligands results in inhibition of T cell proliferation and cytokine secretion.

Purified Anti-Human CD279/PD-1 Antibody [J110] (AGEL2401)

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Description