Recombinant 2019-nCoV Papain-like Protease Protein (His Tag) (RPES0056)
The coronaviral proteases, papain-like protease (PLpro) and 3C-like protease (3CLpro), are attractive antiviral drug targets because they are essential for coronaviral replication. PLpro has the additional function of stripping ubiquitin and ISG15 from host-cell proteins to aid coronaviruses in their evasion of the host innate immune responses. Targeting PLpro with antiviral drugs may have an advantage in not only inhibiting viral replication but also inhibiting the dysregulation of signaling cascades in infected cells that may lead to cell death in surrounding, uninfected cells.
Product Name:
Recombinant 2019-nCoV Papain-like Protease Protein (His Tag)
SKU:
RPES0056
Size:
100µg 1mg
Species:
Virus
Sequence:
Glu1564-Val1880
Accession:
YP_009725299.1
Purity:
> 90 % as determined by reducing SDS-PAGE.
Endotoxin:
< 1.0 EU per µg as determined by the LAL method.
Formulation:
Lyophilized from sterile 20 mM Tris 500mM NaCl, pH 7.4.
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
