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Recombinant 53BP1 Monoclonal Antibody (AGEL6298)

Datasheet MSDS
SKU AGEL6298
Product Type Antibody
Reactivity Human
Applications WB, IHC, IF, ELISA, CHIP, Cut&Tag
Host Species Rabbit
Clonality Monoclonal
Clone C310992
Conjugate Unconjugated
$540 - $738

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Description

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Recombinant 53BP1 Monoclonal Antibody

The Recombinant 53BP1 Monoclonal Antibody is a recombinant rabbit monoclonal antibody (clone C310992) against 53BP1. This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling following DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V(D)J recombination, class switch recombination and at unprotected telomeres. Produced by recombinant technology in Rabbit hosts and purified by Protein A affinity chromatography, this Rabbit IgG antibody is reactive against Human samples.

This antibody is suitable for WB, IHC, IF, ELISA, CHIP and Cut&Tag applications. It has been validated by WB analysis of Hela and IHC analysis of Human colon carcinoma. The target is localized to the nucleus.

Product Name:Recombinant 53BP1 Monoclonal Antibody
SKU:AGEL6298
Size:50 µL, 100 µL
Antibody Type:Recombinant Monoclonal Antibody
Synonyms:53BP, 53BP1, p202, p53BP, p53BP1, TDRD, TDRD30, TP53, TP53BP, TP53BP1, tumor protein p53 binding protein, tumor protein p53 binding protein 1
Reactivity:Human
Immunogen:Recombinant Human 53BP1 protein
Applications:WBIHCIFELISACHIPCut&Tag
Clonality:Recombinant Monoclonal
Clone No:C310992
Host:Rabbit
Isotype:Rabbit IgG
Target:53BP1
Conjugation:Unconjugated
Observed MW:450 kDa
Calculated MW:214 kDa
Recommended Dilution:WB 1:2000-10000; IHC 1:200-1000; IF 1:200-1000; ELISA 1:5000-20000
UniProt:Q12888
Purification:Protein A
Concentration:0.2 mg/mL
Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Storage:Store at -20°C valid for 12 months. Avoid freeze / thaw cycles.
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