The Recombinant ASC Monoclonal Antibody is a recombinant rabbit monoclonal antibody (clone C470965) against ASC. This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Produced by recombinant technology in Rabbit hosts and purified by Protein A affinity chromatography, this Rabbit IgG antibody is reactive against Mouse and Rat samples.
This antibody is suitable for WB, IF, IP and ELISA applications. It has been validated by WB analysis of Mouse spleen. The target is localized to the cytoplasm, nucleus.
![Anti-ASC [R08-1C5] Monoclonal Antibody (AGMB00097)](https://cdn11.bigcommerce.com/s-h68l9z2lnx/images/stencil/590x590/products/271386/693950/anti-asc-r08-1c5-monoclonal-antibody-agmb00097__23896.1774510900.jpg?c=2 "Anti-ASC [R08-1C5] Monoclonal Antibody (AGMB00097)")
