The Recombinant Caveolin 1 Monoclonal Antibody is a recombinant rabbit monoclonal antibody (clone C313330) against Caveolin 1. Caveolin-1 (CAV1), a multifunctional protein, is the main constituent molecule of caveolae and represents a scaffolding molecule for several signaling molecules including epidermal growth factor receptor. Several studies have implicated that a reduced expression of CAV1 was found in cancers including head and neck carcinoma. However, other studies recognize CAV1 as a tumor promoter because CAV1 is overexpressed in various kinds of cancers, especially in oral cancer. Produced by recombinant technology in Rabbit hosts and purified by affinity chromatography, this Rabbit IgG antibody is reactive against Human samples.
This antibody is suitable for WB, IHC-P and IF applications. It has been validated by WB analysis of Hela and IF analysis of Human breast cancer, Hela. The target is localized to the Golgi apparatus membrane. Cell membrane. Membrane>caveola. Membrane raft. Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane. Membrane protein of caveolae.
