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Recombinant CDK8 Monoclonal Antibody (AGEL6417)

Datasheet MSDS
SKU AGEL6417
Product Type Antibody
Reactivity Human, Mouse
Applications WB, IHC
Host Species Rabbit
Clonality Monoclonal
Clone C221111
Conjugate Unconjugated
$606 - $843

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Description

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Recombinant CDK8 Monoclonal Antibody

The Recombinant CDK8 Monoclonal Antibody is a recombinant rabbit monoclonal antibody (clone C221111) against CDK8. Cyclin-dependent kinase 8 (CDK8) is a cell cycle regulator, which can activate cyclin C, act in the G1/S phase, and regulate the normal cell cycle. CDK8 together with Cyclin, Med12 and Med13 form an intermediary complex, which is widely involved in the transmission of information between RNA polymerase II and gene-specific transcription factors, which can activate and inhibit transcription. In addition, CDK8 can activate a variety of signal transduction pathways such as Wnt/β-catenin and Notch, thereby inducing the occurrence and metastasis of malignant tumors such as rectal cancer and melanoma. Produced by recombinant technology in Rabbit hosts and purified by Protein A affinity chromatography, this Rabbit IgG antibody is reactive against Human and Mouse samples.

This antibody is suitable for WB and IHC applications. It has been validated by WB analysis of HeLa, K562, HCT-116 and IHC analysis of Human breast cancer, Mouse colon. The target is localized to the nucleus.

Product Name:Recombinant CDK8 Monoclonal Antibody
SKU:AGEL6417
Size:50 µL, 100 µL
Antibody Type:Recombinant Monoclonal Antibody
Synonyms:CDK, CDK8, Cell division protein kinase 8, K35
Reactivity:Human, Mouse
Immunogen:Recombinant human CDk8 fragment
Applications:WBIHC
Clonality:Recombinant Monoclonal
Clone No:C221111
Host:Rabbit
Isotype:Rabbit IgG
Target:CDK8
Conjugation:Unconjugated
Observed MW:53 kDa
Calculated MW:53 kDa
Recommended Dilution:WB 1:500-1000; IHC 1:50-100
UniProt:P49336
Purification:Protein A
Concentration:1 mg/mL
Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Storage:Store at -20°C valid for 12 months. Avoid freeze / thaw cycles.
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