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Recombinant CENP-A Monoclonal Antibody (AGEL5597)

Datasheet MSDS
SKU AGEL5597
Product Type Antibody
Reactivity Human
Applications WB, IF, ELISA
Host Species Rabbit
Clonality Monoclonal
Clone C370278
Conjugate Unconjugated
$540 - $738

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Description

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Recombinant CENP-A Monoclonal Antibody

The Recombinant CENP-A Monoclonal Antibody is a recombinant rabbit monoclonal antibody (clone C370278) against CENP-A. Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. This gene encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. Centromere protein A is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. Produced by recombinant technology in Rabbit hosts and purified by Protein A affinity chromatography, this Rabbit IgG antibody is reactive against Human samples.

This antibody is suitable for WB, IF and ELISA applications. It has been validated by WB analysis of K562, HeLa, HCT116, Jurkat, MCF-7, HepG2. The target is localized to the nucleus, chromosome, centromere, kinetochore, chromosome, centromere, Localizes exclusively in the kinetochore domain of centromeres. Occupies a compact domain at the inner kinetochore plate stretching across 2 thirds of the length of the constriction but encompassing only one third of the constriction width and height (PubMed:19114591). Phosphorylation at Ser-68 during early mitosis abolishes association with chromatin and centromeres and results in dispersed nuclear location (PubMed:25556658).

Product Name:Recombinant CENP-A Monoclonal Antibody
SKU:AGEL5597
Size:50 µL, 100 µL
Antibody Type:Recombinant Monoclonal Antibody
Synonyms:CenH, CenH3, CENP-A, CENPA
Reactivity:Human
Immunogen:Recombinant Human CENP-A protein
Applications:WBIFELISA
Clonality:Recombinant Monoclonal
Clone No:C370278
Host:Rabbit
Isotype:Rabbit IgG
Target:CENP-A
Conjugation:Unconjugated
Observed MW:16 kDa
Calculated MW:16 kDa
Recommended Dilution:WB 1:2000-10000; IF 1:200-1000; ELISA 1:5000-20000
UniProt:P49450
Purification:Protein A
Concentration:0.2 mg/mL
Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Storage:Store at -20°C valid for 12 months. Avoid freeze / thaw cycles.
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