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Key Features

Recombinant CENP-A Monoclonal Antibody (AGEL6418)

Datasheet MSDS
SKU AGEL6418
Product Type Antibody
Reactivity Human
Applications WB, IHC-P
Host Species Rabbit
Clonality Monoclonal
Clone C321112
Conjugate Unconjugated
€459 - €639

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Description

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Recombinant CENP-A Monoclonal Antibody

The Recombinant CENP-A Monoclonal Antibody is a recombinant rabbit monoclonal antibody (clone C321112) against CENP-A. Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes. Replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. Required for recruitment and assembly of kinetochore proteins, and as a consequence required for progress through mitosis, chromosome segregation and cytokinesis. Produced by recombinant technology in Rabbit hosts and purified by Protein A affinity chromatography, this Rabbit IgG antibody is reactive against Human samples.

This antibody is suitable for WB and IHC-P applications. It has been validated by WB analysis of K562, Hela. The target is localized to the nucleus.

Product Name:Recombinant CENP-A Monoclonal Antibody
SKU:AGEL6418
Size:50 µL, 100 µL
Antibody Type:Recombinant Monoclonal Antibody
Synonyms:CenH, CenH3, CENP-A, CENPA
Reactivity:Human
Immunogen:A synthetic peptide of human CENPA
Applications:WBIHC-P
Clonality:Recombinant Monoclonal
Clone No:C321112
Host:Rabbit
Isotype:Rabbit IgG
Target:CENP-A
Conjugation:Unconjugated
Observed MW:16 kDa
Calculated MW:16 kDa
Recommended Dilution:WB 1:1000-10000; IHC-P 1:100-200
UniProt:P49450
Purification:Protein A
Concentration:1 mg/mL
Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Storage:Store at -20°C valid for 12 months. Avoid freeze / thaw cycles.
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