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Recombinant COPS3 Monoclonal Antibody (AGEL6426)

Datasheet MSDS
SKU AGEL6426
Product Type Antibody
Reactivity Human, Rat, Mouse
Applications WB, ICC/IF, FC
Host Species Rabbit
Clonality Monoclonal
Clone C171120
Conjugate Unconjugated
$606 - $843

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Description

system_update_altDatasheetsystem_update_altMSDS

Recombinant COPS3 Monoclonal Antibody

The Recombinant COPS3 Monoclonal Antibody is a recombinant rabbit monoclonal antibody (clone C171120) against COPS3. Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. Produced by recombinant technology in Rabbit hosts and purified by Protein A affinity chromatography, this Rabbit IgG antibody is reactive against Human, Mouse and Rat samples.

This antibody is suitable for WB, ICC/IF and FC applications. It has been validated by WB analysis of Mouse brain, Rat brain and IF analysis of HeLa. The target is localized to the cytoplasm, nucleus, signalosome.

Product Name:Recombinant COPS3 Monoclonal Antibody
SKU:AGEL6426
Size:50 µL, 100 µL
Antibody Type:Recombinant Monoclonal Antibody
Synonyms:Constitutive photomorphogenic homolog subunit 3, COP 9 (constitutive photomorphogenic) subunit 3, COP 9 complex homolog subunit 3, COP 9 complex S3, COP 9 complex subunit 3, COP 9 constitutive photomorphogenic homolog subunit 3, COP 9 homolog, COP 9 signalosome complex subunit 3, COP 9 signalosome subunit 3, COP 9 subunit 3, COP9 (constitutive photomorphogenic) subunit 3, COP9 complex homolog subunit 3, COP9 complex S3, COP9 complex subunit 3, COP9 constitutive photomorphogenic homolog subunit 3, COP9 homolog, COP9 signalosome complex subunit 3, COP9 signalosome subunit 3, COP9 subunit 3, COPS, COPS 3, COPS3, Csn, CSN 3, CSN3, JAB 1 containing signalosome subunit 3, JAB1 containing signalosome subunit 3, JAB1-containing signalosome subunit 3, SGN, SGN 3, SGN3, Signalosome subunit 3
Reactivity:Human, Mouse, Rat
Immunogen:A synthetic peptide of Human COPS3
Applications:WBICC/IFFC
Clonality:Recombinant Monoclonal
Clone No:C171120
Host:Rabbit
Isotype:Rabbit IgG
Target:COPS3
Conjugation:Unconjugated
Observed MW:48 kDa
Calculated MW:48 kDa
Recommended Dilution:WB 1:1000-10000; ICC/IF 1:200-500; FCM 1:50-100
UniProt:Q9UNS2
Purification:Protein A
Concentration:1 mg/mL
Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Storage:Store at -20°C valid for 12 months. Avoid freeze / thaw cycles.
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