The Recombinant Cyclin D2 Monoclonal Antibody is a recombinant rabbit monoclonal antibody (clone C721452) against Cyclin D2. Cyclin D2 (CCND2) belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. CCND2 forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. Produced by recombinant technology in Rabbit hosts and purified by Protein A affinity chromatography, this Rabbit IgG antibody is reactive against Human and Rat samples.
This antibody is suitable for WB and IHC applications. It has been validated by WB analysis of HEK-293, HeLa, Caco-2 and IHC analysis of Human colon cancer, Human ovarian cancer, Rat stomach. The target is localized to the cytoplasm, nucleus.