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Recombinant DR5 Monoclonal Antibody (RMEA1478)

Datasheet MSDS
SKU RMEA1478
Product Type Antibody
Reactivity Human
Applications WB, IHC
Host Species Rabbit
Clonality Monoclonal
Clone C321478
Conjugate Unconjugated
€459 - €639

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Description

system_update_altDatasheetsystem_update_altMSDS

Recombinant DR5 Monoclonal Antibody

The Recombinant DR5 Monoclonal Antibody is a recombinant rabbit monoclonal antibody (clone C321478) against DR5. DR5, also known as CD262, TNFRSF10B, TRAILR2, TRICK2 and KILLER, is a widely expressed single-pass type I membrane protein belonging to the tumour necrosis factor receptor superfamily (TNFRSF). It is a receptor for TNF-related apoptosis-inducing ligand (TRAIL), which is a member of the tumor necrosis factor (TNF) family of cytokines and induces apoptosis in a wide variety of cells. DR5 contains two extracellular cysteine-rich repeats, typical for TNF receptor (TNFR) family members, and a cytoplasmic death domain (DD), through which DR5 is capable to transmit the apoptotic signal. Produced by recombinant technology in Rabbit hosts and purified by Protein A affinity chromatography, this Rabbit IgG antibody is reactive against Human samples.

This antibody is suitable for WB and IHC applications. It has been validated by WB analysis of K562, HT-1080, HeLa, HCT-116, LNCaP and IHC analysis of Human colon cancer, Human endometrial cancer. The target is localized to the cytoplasm, membrane.

Product Name:Recombinant DR5 Monoclonal Antibody
SKU:RMEA1478
Size:50 µL, 100 µL
Antibody Type:Recombinant Monoclonal Antibody
Synonyms:CD262, Death Receptor, Death Receptor 5, DR5, KILLER, KILLER/DR, KILLER/DR5, PRO, PRO186, TNF-Related Apoptosis-Inducing Ligand Receptor, TNF-Related Apoptosis-Inducing Ligand Receptor 2, TNFRSF10B, TRAIL Receptor, TRAIL Receptor 2, TRAIL-R, TRAIL-R2, TRAILR, TRAILR2, TRICK, TRICK2, TRICK2A, TRICK2B, TRICKB, Tumor Necrosis Factor Receptor Superfamily Member 10B, UNQ, UNQ160, ZTNFR, ZTNFR9
Reactivity:Human
Immunogen:Recombinant human DR5 fragment
Applications:WBIHC
Clonality:Recombinant Monoclonal
Clone No:C321478
Host:Rabbit
Isotype:Rabbit IgG
Target:DR5
Conjugation:Unconjugated
Observed MW:40, 48 kDa
Calculated MW:48 kDa
Recommended Dilution:WB 1:1000-5000; IHC 1:200-1000
UniProt:O14763
Purification:Protein A
Concentration:1 mg/mL
Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Storage:Store at -20°C valid for 12 months. Avoid freeze / thaw cycles.
Product ImageofImmunohistochemistry of paraffin-embedded Human colon cancer using DR5 Monoclonal Antibody at dilution of 1:1000.
Product ImageImmunohistochemistry of paraffin-embedded Human endometrial cancer using DR5 Monoclonal Antibody at dilution of 1:1000.
Product ImageWestern Blot with DR5 Monoclonal Antibody at dilution 1:5000. Lane 1: K562, Lane 2: HT-1080, Lane 3: HeLa, Lane 4: HCT-116, Lane 5: LNCaP Observed-MW:40,48 kDa Calculated-MW:48 kDa
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