The Recombinant FKBP52 Monoclonal Antibody is a recombinant rabbit monoclonal antibody (clone C173255) against FKBP52. FKBP52 (FK506 binding protein 4) is a member of the immunophilin protein family that comprises intracellular protein effectors of immunosuppressive drugs, and it is known as a steroid receptor-associated protein. As a novel regulator of microtubule dynamics, FKBP52 is associated with the motor protein dynein and with the cytoskeleton during mitosis. FKBP52 is highly expressed in CNS regions susceptible to Alzheimer's, and plays a role in modulating toxicity of Abeta peptides. Produced by recombinant technology in Rabbit hosts and purified by affinity chromatography, this Rabbit IgG antibody is reactive against Human, Mouse, Rat and Hamster samples.
This antibody is suitable for WB and IF applications. It has been validated by WB analysis of Jurkat, C6, CHO-K1, Hela and IHC analysis of Hela. The target is localized to the Cytoplasm>cytosol. Nucleus. Cytoplasm>cytoskeleton.