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Key Features

Recombinant GBA Monoclonal Antibody (AGEL6888)

Datasheet MSDS
SKU AGEL6888
Product Type Antibody
Reactivity Human, Rat
Applications WB, IHC, IF, ELISA
Host Species Rabbit
Clonality Monoclonal
Clone C711583
Conjugate Unconjugated
$606 - $843

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Description

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Recombinant GBA Monoclonal Antibody

The Recombinant GBA Monoclonal Antibody is a recombinant rabbit monoclonal antibody (clone C711583) against GBA. Beta-Glucosylceramidase (β-GC) is a lysosomal enzyme that catalyzes the hydrolysis of glucocerebroside into free ceramide and glucose. Lysosomal breakdown of glucocerebroside is required for cellular metabolism of complex lipids and proper turnover of cellular membrane. In the absence of GBA, the gene that encodes β-GC, autophagic lysosome reformation is altered, suggesting that β-GC activity is critical to maintain functional lysosomes. Produced by recombinant technology in Rabbit hosts and purified by Protein A affinity chromatography, this Rabbit IgG antibody is reactive against Human and Rat samples.

This antibody is suitable for WB, IHC, IF and ELISA applications. It has been validated by WB analysis of U-87 MG, Saos-2, C6 and IHC analysis of Human kidney. The target is localized to the lysosome.

Product Name:Recombinant GBA Monoclonal Antibody
SKU:AGEL6888
Size:50 µL, 100 µL
Antibody Type:Recombinant Monoclonal Antibody
Synonyms:7-O-sialyl GD3, 9-O-sialyl GD3, ACID, acid (includes glucosylceramidase), Acid beta glucosidase, Acid beta-glucosidase, Alglucerase, beta, Beta glucocerebrosidase, BETA GLUCOSIDASE, Beta-glucocerebrosidase, betaGC, D glucosyl N acylsphingosine glucohydrolase, D-glucosyl-N-acylsphingosine glucohydrolase, EC 3.2.1.45, GBA, Gba protein, GBA1, GC, GCase, GCB, GLCM, GLUC, Glucocerebrosidase, Glucocerebrosidase (alt.), GLUCOCEREBROSIDASE PSEUDOGENE, Glucosidase, Glucosidase beta, Glucosylceramidase, Imiglucerase, Lysosomal glucocerebrosidase, OTTHUMP00000033992, OTTHUMP00000033993
Reactivity:Human, Rat
Immunogen:The specific immunogen used to produce this antibody is proprietary information.
Applications:WBIHCIFELISA
Clonality:Recombinant Monoclonal
Clone No:C711583
Host:Rabbit
Isotype:Rabbit IgG
Target:GBA
Conjugation:Unconjugated
Observed MW:65 kDa
Calculated MW:60 kDa
Recommended Dilution:WB 1:1000-20000; IHC 1:200-500; IF 1:200-1000; ELISA 1:5000-20000
UniProt:P04062, P17439
Purification:Protein A
Concentration:1 mg/mL
Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Storage:Store at -20°C valid for 12 months. Avoid freeze / thaw cycles.
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