The Recombinant GluR-2 Monoclonal Antibody is a recombinant rabbit monoclonal antibody (clone C110902) against GluR-2. Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. Produced by recombinant technology in Rabbit hosts and purified by Protein A affinity chromatography, this Rabbit IgG antibody is reactive against Human, Mouse and Rat samples.
This antibody is suitable for WB, IHC, IF, IP and ELISA applications. It has been validated by IHC analysis of Mouse brain. The target is localized to the cell membrane, multi-pass membrane protein, endoplasmic reticulum membrane, multi-pass membrane protein, cell junction, synapse, postsynaptic cell membrane, multi-pass membrane protein, cell junction, synapse, postsynaptic density membrane, multi-pass membrane protein, Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression (By similarity). Displays a somatodendritic localization and is excluded from axons in neurons (By similarity).
