The Recombinant GSK3β Monoclonal Antibody is a recombinant rabbit monoclonal antibody (clone C110932) against GSK3β. The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Produced by recombinant technology in Rabbit hosts and purified by Protein A affinity chromatography, this Rabbit IgG antibody is reactive against Human, Mouse, Rat and Rabbit samples.
This antibody is suitable for WB, IHC, IF, IP and ELISA applications. It has been validated by WB analysis of HeLa, HepG2, Jurkat, A549, K562, NIH/3T3, Mouse brain, Mouse kindey, C6, Rat brain, Rat kindey, Rat heart. The target is localized to the cytoplasm, nucleus, cell membrane, The phosphorylated form shows localization to cytoplasm and cell membrane (PubMed:20937854). The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosphorylated form to the cell membrane (PubMed:20937854).
