The Recombinant HER4/ErbB4 Monoclonal Antibody is a recombinant rabbit monoclonal antibody (clone C341494) against HER4/ErbB4. HER4/ErbB4, like other receptor tyrosine kinase family members, has four ectodomains, a single transmembrane domain and a cytoplasmic tail containing the active tyrosine kinase domain. By binding to neuregulins and/or EGF family ligands, ErbB4 forms either a homodimer or heterodimer with other ErbB family members, which results in receptor activation and signaling. ErbB4 is ubiquitously expressed with the highest expression occurring in brain and heart. Produced by recombinant technology in Rabbit hosts and purified by Protein A affinity chromatography, this Rabbit IgG antibody is reactive against Human samples.
This antibody is suitable for IHC and IF applications. It has been validated by IHC analysis of Human breast cancer, Human cervical cancer and IF analysis of SK-BR-3. The target is localized to the cytoplasm, membrane.
Product Name:
Recombinant HER4/ErbB4 Monoclonal Antibody
SKU:
AGEL6799
Size:
50 µL, 100 µL
Antibody Type:
Recombinant Monoclonal Antibody
Synonyms:
4ICD, ALS, ALS19, Avian erythroblastic leukemia viral oncogene homolog 4, Avian erythroblastic leukemia viral v erb b2 oncogene homolog 4, E4ICD, EC 2.7.10.1, ERBB, ERBB4, ERBB4 intracellular domain, HER, HER 4, HER4, HER4/ErbB, HER4/ErbB4, human epidermal growth factor receptor 4, Mer4, MGC138404, Oncogene ERBB4, p180erbB, p180erbB4, Proto-oncogene-like protein c-ErbB, Proto-oncogene-like protein c-ErbB-4, Receptor protein tyrosine kinase erbB 4 precursor, Receptor tyrosine protein kinase erbB 4, Receptor tyrosine-protein kinase erbB, Receptor tyrosine-protein kinase erbB-4, s80HER4, Tyrosine kinase type cell surface receptor HER4, Tyrosine kinase-type cell surface receptor HER, Tyrosine kinase-type cell surface receptor HER4, v erb a avian erythroblastic leukemia viral oncogene homolog like 4, v erb a erythroblastic leukemia viral oncogene homolog 4, v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian), V-ERB-B2 avian erythroblastic leukemia viral oncogene homolog 4, Verba avian erythroblastic leukemia viral oncogene homolog like 4, Verba erythroblastic leukemia viral oncogene homolog 4, VERBB2
Reactivity:
Human
Immunogen:
Recombinant human HER4/ErbB4 fragment
Applications:
IHCIF
Clonality:
Recombinant Monoclonal
Clone No:
C341494
Host:
Rabbit
Isotype:
Rabbit IgG
Target:
HER4/ErbB4
Conjugation:
Unconjugated
Recommended Dilution:
IHC 1:200-1000; IF 1:50
UniProt:
Q15303
Purification:
Protein A
Concentration:
1 mg/mL
Buffer:
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Storage:
Store at -20°C valid for 12 months. Avoid freeze / thaw cycles.
