Recombinant Human Annexin A3/ANXA3 Protein (RPES2685)

SKU:
RPES2685
€196

Description

ELISA Kit Technical Manual

Recombinant Human Annexin A3/ANXA3 Protein

Background:Annexin A3?ANXA3?contains 4 annexin repeats and belongs to the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. It is abnormally expressed in fetuses of both IVF and ICSI, which may contribute to the increase risk of birth defects in these ART. ANXA3 is Inhibitor of phospholipase A2 and cleaves the cyclic bond of inositol 1,2-cyclic phosphate to form inositol 1-phosphate. it also also play a role in anti-coagulant properties.
Name:Recombinant Human Annexin A3/ANXA3 Protein
Size:10µg
Assay Genie SKU:RPES2685
Synonyms:35-alpha calcimedin;Annexin III;Annexin-3;Inositol 1;2-cyclic phosphate 2-phosphohydrolase;Lipocortin III;Placental anticoagulant protein III;PAP-III;ANX3
Species:Human
Expression host:E.coli
Sequence:Met 1-Asp323
Accession:P12429
Mol Mass:36.4 kDa
AP Mol Mass:33 kDa
Tag:
Purity:> 95 % as determined by reducing SDS-PAGE.
Endotoxin:< 1.0 EU per µg as determined by the LAL method.
Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8? for 2-7 days. Aliquots of reconstituted samples are stable at < -20'C for 3 months.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Formulation:Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4.
Reconstitution:Please refer to the printed manual for detailed information.
UniProt Protein Function:ANXA3: a calcium/phospholipid-binding protein and inhibitor of phospholipase A2, Possesses anti-coagulant properties. Cleaves the cyclic bond of inositol 1,2-cyclic phosphate to form inositol 1-phosphate. Annexins are a family of structurally related proteins whose common property is calcium-dependent binding to phospholipids. There are at least ten different annexins in mammalian species. Annexins do not contain signal peptides, yet some annexins (A1, A2 and A5) appear to be secreted in a physiologically regulated fashion.
UniProt Protein Details:

Protein type:Calcium-binding

Chromosomal Location of Human Ortholog: 4q21.21

Cellular Component: cytoplasm; membrane; phagocytic vesicle membrane; plasma membrane; specific granule

Molecular Function:calcium-dependent phospholipid binding; calcium-dependent protein binding

Biological Process: defense response to bacterium; neutrophil degranulation; phagocytosis; positive regulation of angiogenesis; positive regulation of transcription factor activity

NCBI Summary:This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions in the inhibition of phopholipase A2 and cleavage of inositol 1,2-cyclic phosphate to form inositol 1-phosphate. This protein may also play a role in anti-coagulation. [provided by RefSeq, Jul 2008]
UniProt Code:P12429
NCBI GenInfo Identifier:113954
NCBI Gene ID:306
NCBI Accession:P12429.3
UniProt Secondary Accession:P12429,Q6LET2, B2R9W6,
UniProt Related Accession:P12429
Molecular Weight:36,375 Da
NCBI Full Name:Annexin A3
NCBI Synonym Full Names:annexin A3
NCBI Official Symbol:ANXA3
NCBI Official Synonym Symbols:ANX3
NCBI Protein Information:annexin A3
UniProt Protein Name:Annexin A3
UniProt Synonym Protein Names:35-alpha calcimedin; Annexin III; Annexin-3; Inositol 1,2-cyclic phosphate 2-phosphohydrolase; Lipocortin III; Placental anticoagulant protein III; PAP-III
Protein Family:Annexin
UniProt Gene Name:ANXA3
UniProt Entry Name:ANXA3_HUMAN
View AllClose

Additional Information

Product type:
Recombinant Protein
Host species:
E.coli
Reactivity:
Human
View AllClose